JAK1, Janus kinase 1, 3716

N. diseases: 239; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.130 Biomarker disease BEFREE Hence, inhibition of these changes by treatment with a JAK1/2 inhibitor suggests that such treatment may help retard progression of early diabetic kidney disease in patients. 28554737 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.130 Biomarker disease BEFREE Finally, a yet unpublished Phase 2 multicentre, randomised, double-blind, placebo-controlled study of the efficacy of a selective JAK1 and JAK2 inhibitor has been conducted in type 2 diabetic participants with DKD. 27333885 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.130 GeneticVariation disease GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897 2015
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.130 AlteredExpression disease BEFREE Jak-1, -2, and -3 as well as Stat-1 and -3 were expressed at higher levels in patients with diabetic nephropathy than in control subjects. 19017763 2009