|
Sarcoma
|
0.310 |
GenomicAlterations
|
group |
CGI |
|
|
|
|
Other emphysema
|
0.200 |
Biomarker
|
phenotype |
MGD |
|
|
|
|
Zinc deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced activator protein-1 activation.
|
16484283 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor suppressor Pdcd4 has recently been shown to inhibit invasion by activating activator protein-1 (AP-1); however, little is known of the functionally significant Pdcd4-target genes.
|
17297470 |
2007 |
|
Anoxia
|
0.020 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia/reoxygenation activated Plk3 in HCE cells to directly phosphorylate c-Jun proteins at phosphorylation sites Ser-63 and Ser-73, and to increase DNA binding activity of c-Jun, detected by EMSA.
|
18650425 |
2008 |
|
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain-containing 3 and induces activator protein 1 activation.
|
27080060 |
2016 |
|
Nasopharyngeal carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
NPC tissues showed higher expression of TGFβRI and AP-1 but lower expression of PDCD4 than normal tissues (all P < 0.05).
|
29017171 |
2017 |
|
Niemann-Pick Disease, Type C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NPC tissues showed higher expression of TGFβRI and AP-1 but lower expression of PDCD4 than normal tissues (all P < 0.05).
|
29017171 |
2017 |
|
Classical Hodgkin's Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Classical Hodgkin Lymphoma (cHL) is primarily a B cell lymphoid neoplasm and a member of the CD30-positive lymphomas. cHL and the other CD30-positive lymphomas are characterized by the elevated expression and/or constitutive activation of the activator protein-1 (AP-1) family transcription factors, c-Jun and JunB; however, the specific roles they play in the pathobiology of cHL are unclear.
|
30375407 |
2018 |
|
Adult Classical Hodgkin Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Classical Hodgkin Lymphoma (cHL) is primarily a B cell lymphoid neoplasm and a member of the CD30-positive lymphomas. cHL and the other CD30-positive lymphomas are characterized by the elevated expression and/or constitutive activation of the activator protein-1 (AP-1) family transcription factors, c-Jun and JunB; however, the specific roles they play in the pathobiology of cHL are unclear.
|
30375407 |
2018 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Astrocytoma specimens showed lesser extent of immunostaining for IL-13Rα2 and three AP-1 factors compared to GBM specimens.
|
30572904 |
2018 |
|
Childhood Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Astrocytoma specimens showed lesser extent of immunostaining for IL-13Rα2 and three AP-1 factors compared to GBM specimens.
|
30572904 |
2018 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
|
10924853 |
2000 |
|
Hyperglycemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells.
|
11053476 |
2000 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.
|
16652374 |
2006 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.
|
16652374 |
2006 |
|
Sarcoma
|
0.310 |
AlteredExpression
|
group |
BEFREE |
JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas.
|
17418412 |
2007 |
|
Malignant neoplasm of soft tissue
|
0.010 |
AlteredExpression
|
group |
BEFREE |
JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas.
|
17418412 |
2007 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer.
|
17672916 |
2007 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer.
|
17672916 |
2007 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
JUN and two of the miRNA targets (CCND2 and PTPN1) in the network have previously been associated with schizophrenia.
|
17849003 |
2007 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Activator protein-1 (AP-1) regulates the expression of several genes involved in human tumorigenesis.
|
19435822 |
2009 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Transcription factor AP-1 is composed of c-Fos and c-Jun and mediates inflammation and carcinogenesis.
|
19495976 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection.
|
19758438 |
2009 |
|
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcription factor AP-1 promotes growth and radioresistance in prostate cancer cells.
|
19787273 |
2009 |