Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE We identify the ERN1-JNK-JUN pathway as a novel regulator of MEK inhibitor response in KRAS mutant colon cancer. 30482246 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 AlteredExpression disease BEFREE Taken together, these data indicated that silibinin inhibits LoVo cell invasion with the reduction of MMP-2 presentation by attenuating AP-1 binding activity, suggesting a novel antimetastatic application for silibinin in colon cancer chemoprevention. 23210512 2012
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE Taken together, these results suggest that natural chemopreventive compounds may have differential biological functions on the signal transduction pathways such as AP-1 in the intervention of colon cancer progression and carcinogenesis. 15139522 2004
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. 14712303 2004
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE We studied the effects of bile acids on inducibility of the transcription factor AP-1 in human colon carcinoma LoVo cells. 8631127 1996