|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased KAI1 expression significantly correlated with distant metastases (Mann-Whitney, p = 0.0001, mRNA; p = 0.033, protein), cancer-specific survival (Cox regression analysis p = 0.0002, mRNA; 0.0493, protein) and overall patient survival (p = 0.0001, mRNA).
|
12530084 |
2003 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression.
|
14612520 |
2003 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, tumor suppressor genes such as KAI1 are expressed at reduced levels, thereby enhancing the ability of pancreatic cells to form metastases.
|
12120231 |
2001 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
KAI1 is a metastasis suppressor gene which is capable of inhibiting the processes of tumor metastasis without affecting tumorigenicity per se.
|
10913345 |
2000 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Induction of KAI-1 expression in metastatic cancer cells by phorbol esters.
|
10779634 |
2000 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These results, combined with recent studies of the tumor metastasis suppressor gene KAI1 and plasminogen activator inhibitor 1 (PAI1), define a new category of molecular targets of p53 that have the potential to negatively regulate tumor invasion and/or metastasis.
|
10692390 |
2000 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data demonstrate that the KAI1 mRNA expression and the KAI1 protein level increase in an earlier tumor stage of colorectal cancer, decrease in advanced stages, and are lost in metastases.
|
10568187 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
This differential expression of the metastasis suppressor gene KAI1 in primary prostate cancers may have important prognostic implications for the development of subsequent metastases.
|
10440748 |
1999 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, most of the primary HCC cells in samples with metastases showed only faint or moderate KAI1 mRNA expression predominantly in the perinuclear regions.
|
9828210 |
1998 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, KAI1 mRNA expression was similar in primary esophageal and gastric cancer samples with or without metastases.
|
9485031 |
1998 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting the metastatic process in animals.
|
9736732 |
1998 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistical analysis of KAI1 mRNA levels and clinical parameters of the patients revealed that KAI1 mRNA levels were significantly higher in non-metastasized tumors compared with tumors in which lymph node or distant metastases were present.
|
9699525 |
1998 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It is suggested that KAI1 gene expression may be related to the metastases of hepatocellular carcinoma.
|
9894767 |
1998 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
To evaluate whether dysregulation of KAI1 occurs during the progression of human prostatic cancer, protein expression, mutation, and allelic loss of KAI1 were analyzed using a tissue bank of 98 primary cancers and 32 metastases.
|
8813131 |
1996 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correlation of the mRNA levels obtained by Northern blot analysis with clinical parameters of the patients revealed that KAI1 mRNA levels were significantly higher (P < 0.01) in earlier tumor stages (I, II), compared with advanced tumor stages (III, IV) in which lymph node or distant metastases were present.
|
8895737 |
1996 |