|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AREG and EREG mRNA expression was strongly correlated in both the primary tumor (Rs = 0.81, p < 0.0001) and the liver metastases (Rs = 0.87, p < 0.0001).
|
22409860 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, tumors from mice treated with TGFalpha, AR and CR AS MBOs showed a significant reduction of microvessel count, as compared with tumors from untreated mice or from mice treated with a single AS MBO.
|
11127817 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While recombinant AREG did not impact mammary tumour cell proliferation <i>in vitro</i> despite inducing a dose-dependent increase in phosphorylated EGFR, intranasal administration of AREG resulted in a ten-fold increase in pulmonary metastatic tumour burden <i>in vivo</i>.
|
30713780 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, the result from study in vivo showed that the silencing AREG expression by AREG knocked down inhibited tumor growth in nude mice.
|
31466817 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stimulation with the EGF-like growth factor Amphiregulin (AREG) markedly enhanced Treg cell function in vitro, and in a colitis and tumor vaccination model we showed that AREG was critical for efficient Treg cell function in vivo.
|
23333074 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Northern blot analysis revealed that only one cell line and no tumor specimens expressed AR mRNA.
|
9796995 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Blocking AR/EGFR signaling in Tregs with Gefitinib also enhanced anti-tumor immunity and decreased tumor size in a mouse xenograft tumor model.
|
26451607 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
First, upstream molecules, including epiregulin (EREG) and amphiregulin (AREG), might play different roles according to their abnormal levels in tumor tissue and serum.
|
27422777 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EGF and AREG were associated with estradiol receptors, small tumour size, low histoprognostic grading, high HER4 levels.
|
17962208 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EREG and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site, which may explain the association of primary tumour site and EREG/AREG expression with anti-EGFR therapy efficacy.
|
27272216 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No obvious correlation was observed between the AR mRNA levels and the histological types or tumor staging of gastric carcinoma.
|
8407551 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Microarray analysis of colon-derived epithelial cells revealed a hypoxia-dependent increase in the expression of amphiregulin, an EGF receptor (EGFR) ligand that activates epithelial proliferation and has been associated with the development of colonic tumors.
|
16207795 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
For validation studies, we utilized an independent set of meningioma tumor tissue samples (Grade I, <i>n</i> = 20; Grade II, <i>n</i> = 10; Grade III, <i>n</i> = 6), and found that the expressions of amphiregulin and Caspase3 are significantly increased in all grades of meningiomas either at the transcriptional or protein level, respectively.
|
31649887 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The clones expressing AR antisense RNA showed a reversion of the malignant phenotype when injected in nude mice, since a significant reduction of tumor intake was observed coincident with a significant tumor mass reduction (> 96%).
|
10597254 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A greater proportion of well-differentiated tumors (71%) were positive for AR expression than were poorly differentiated tumors (18%).
|
1596904 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of YAP, TAZ and AREG was correlated with the volumetric dimensions of tumors on contrast-enhanced magnetic resonance imaging (ceMRI).
|
28430338 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Production of AREG is triggered by DNA damage to stromal cells, which passively enter senescence in the tumor microenvironment (TME), a process that remarkably enhances cancer malignancy including acquired resistance mediated by EGFR.
|
31493351 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Amphiregulin (AREG), a target gene for Yes-associated protein (YAP), is a known oncogenic component of the Hippo pathway; however, the tumor-suppressive effect of RASSF1A on AREG in regard to regulation of the Hippo pathway remains unclear in HCC.
|
23594797 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that KRAS wild-type (WT) tumor cell-line models chronically adapted to grow in the presence of CTX could be interrogated to establish if the positive predictive value of the mRNAs coding for the EGFR ligands amphiregulin (AR) and epiregulin (EPI) could be significantly altered during and/or after treatment with CTX.
|
21161326 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In a comparison of RNA expression patterns in tumors and uninvolved lung, overexpression of EGFR was found in 45% (22 of 44) of tumors, while overexpression of TGF-alpha was seen in 61% (22 of 36) of tumors, and decreased expression of AR was seen in 63% (22 of 35) of tumors.
|
7683573 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a mouse model of BRCA1-related BC, cancer-associated AhR and AREG control tumor growth and production of chemokines to attract monocytes and activate proangiogenic function of macrophages in the tumor microenvironment.
|
30733286 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trop2+/AREG+ protein coexpression were associated with Tumor Node Metastasis (TNM) stage (χ<sup>2</sup> = 50.345, P < 0.001), tumor size (χ<sup>2</sup> = 40.349, P < 0.001), lymph node metastases (χ<sup>2</sup> = 26.481, P < 0.001), and distant metastases (χ<sup>2</sup> = 8.387, P = 0.039).
|
28256068 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular characteristics were correlated with response, progression-free survival (PFS), overall survival (OS). mRNA expression was evaluated using ROC-analysis in 192 tumors (AREG high n = 31 vs. low n = 161; EREG high n = 89 vs. low n = 103).
|
26284333 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
For example, the concomitant presence of the EGF receptor and its ligands EGF, TGF-alpha, and/or amphiregulin is associated with enhanced tumor aggressiveness and shorter survival periods following tumor resection.
|
10449972 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, immunohistochemical detection of AR and CR-1 in tumor tissue revealed different patterns of growth-factor localization in different types of transgenic mouse mammary-derived tumors.
|
8561865 |
1996 |