|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation.
|
31298420 |
2020 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation.
|
31298420 |
2020 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation.
|
31298420 |
2020 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Kaplan-Meier analysis encompassing only malignant tumours showed similar results indicating that AREG is associated with astrocytoma patient survival independently from astrocytoma grade.
|
31031857 |
2019 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
AREG was also designated to be a promising marker for several types of cancer however precious little data about AREG role in the most frequent and generally lethal human brain tumours - astrocytomas reported up to date.
|
31031857 |
2019 |
|
Primary biliary cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, we demonstrated increased AREG levels in livers from patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
|
30411380 |
2019 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the role of AREG in human choriocarcinoma cell proliferation.
|
31092430 |
2019 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gastrointestinal amphiregulin was significantly lower in acute graft-versus-host disease biopsies (median score 1), ulcerative colitis (median score 1.5), and cytomegalovirus colitis (median score 1) than in normal colon (median score 2, p = 0.004, p = 0.03, p = 0.009 respectively).
|
30425334 |
2019 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results identify amphiregulin as a key player in injury-induced kidney fibrosis and suggest therapeutic or diagnostic applications of soluble amphiregulin in kidney disease.
|
31676723 |
2019 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also found that the expression of amphiregulin, a member of the epidermal growth factor (EGF) family, was correlated with IL13Rα2 expression in cultured melanoma cells, xenograft tumour tissues and melanoma clinical samples.
|
30718742 |
2019 |
|
Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
For validation studies, we utilized an independent set of meningioma tumor tissue samples (Grade I, <i>n</i> = 20; Grade II, <i>n</i> = 10; Grade III, <i>n</i> = 6), and found that the expressions of amphiregulin and Caspase3 are significantly increased in all grades of meningiomas either at the transcriptional or protein level, respectively.
|
31649887 |
2019 |
|
Nasal Polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp.
|
30888496 |
2019 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, the finding that proximal tubule cell-specific amphiregulin knockout mice were protected from fibrosis after ischemia-reperfusion injury or unilateral ureteral obstruction demonstrates that amphiregulin was necessary for the development of fibrosis.
|
31676723 |
2019 |
|
Ovarian Hyperstimulation Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that granulosa cell-secreted AREG plays an important role in the development of OHSS, suggesting that the EGFR/HER2-mediated signaling could be a novel drug target for the prevention and treatment of OHSS.
|
31167229 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis.
|
31676723 |
2019 |
|
Actinic cheilitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
AC conditioned media from older lymphocytes had decreased levels of amphiregulin (367 ± 208 pg/mL vs 904 ± 323 pg/mL; p = .018) and IGF-I (845 ± 88 ng/mL vs 1100 ± 48 ng/mL; p = .032) compared with younger AC lymphocytes.
|
30329021 |
2019 |
|
Adult Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
For validation studies, we utilized an independent set of meningioma tumor tissue samples (Grade I, <i>n</i> = 20; Grade II, <i>n</i> = 10; Grade III, <i>n</i> = 6), and found that the expressions of amphiregulin and Caspase3 are significantly increased in all grades of meningiomas either at the transcriptional or protein level, respectively.
|
31649887 |
2019 |
|
Anaplastic astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GBM tissue disclosed elevated AREG mRNA expression but reduced AREG protein level as compared to grade II and grade III astrocytomas (p<0.001).
|
31031857 |
2019 |
|
Cytomegaloviral colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gastrointestinal amphiregulin was significantly lower in acute graft-versus-host disease biopsies (median score 1), ulcerative colitis (median score 1.5), and cytomegalovirus colitis (median score 1) than in normal colon (median score 2, p = 0.004, p = 0.03, p = 0.009 respectively).
|
30425334 |
2019 |
|
Increased drug resistance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pretreatment with exogenous recombinant AREG markedly increased drug resistance against VCR in OSCC cells, as assessed by an MTT assay.
|
31485602 |
2019 |
|
Primary sclerosing cholangitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, we demonstrated increased AREG levels in livers from patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
|
30411380 |
2019 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Research is lacking on the role of AREG in invasive breast cancer and the co-expression with androgen receptor (AR) status.
|
31040043 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that miR-449a was downregulated while AREG was upregulated in cerebral ischemic injury, and the recovery of neurological function can be obtained following the overexpression of miR-449a and the knockdown of AREG in an I/R injury model. miR-449a functions in ischemic stroke via directly targeting AREG.
|
30773606 |
2019 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
For validation studies, we utilized an independent set of meningioma tumor tissue samples (Grade I, <i>n</i> = 20; Grade II, <i>n</i> = 10; Grade III, <i>n</i> = 6), and found that the expressions of amphiregulin and Caspase3 are significantly increased in all grades of meningiomas either at the transcriptional or protein level, respectively.
|
31649887 |
2019 |
|
IMMUNE SUPPRESSION
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In light of these findings, we discuss whether, by locally activating TGFβ, T<sub>reg</sub> -derived Amphiregulin may contribute to both wound repair and immune suppression.
|
30866049 |
2019 |