AREG, amphiregulin, 374

N. diseases: 221; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.320 AlteredExpression disease BEFREE Hypoxia-inducible factors are stabilized and provide protection from ischemia and reperfusion injury in the setting of myocardial ischemia.In the setting of ischemia, myocyte-specific hypoxia-inducible factor 2A induces expression of amphiregulin, which is an epidermal growth factor that binds to epidermal growth factor receptor 1 (ERBB1) in the myocardium. 31794514 2020
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.320 AlteredExpression disease BEFREE These studies indicate that HIF2-alpha induces myocardial AREG expression in cardiac myocytes, which increases myocardial ischemia tolerance. 29483579 2018
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.320 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005