|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
After the age of 60 years, patients with LQT2 had significantly lower risk of AF compared with genotype-negative controls (hazard ratio=0.07; 95% CI, 0.01-0.53, <i>P</i>=0.011).
|
31610692 |
2019 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
BEFREE |
Various genes involved in Ca<sup>2+</sup> handling or gap junction formation ( Ryr2, Jph2, Gja5), potassium channels ( Kcnh2, Kcnk3), and genes implicated in atrial fibrillation ( Tbx5) were part of this ETV1-driven gene regulatory network.
|
29930145 |
2018 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, the underlying basis of AF and its pharmacological treatment remain incompletely understood in the context of SQT1.
|
30687112 |
2018 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A benign variety of the disease has been observed in children with atrial fibrillation and a KCNH2-V141M mutation, and recently a mutation in the cardiac Cl/HCO<sub>3</sub> exchanger AE3 was found to cause SQTS.
|
29501667 |
2018 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles.
|
29085299 |
2017 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation.
|
28676183 |
2017 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together with the findings that caveolin-1 interacts with potassium channels Kir2.1, KCNH2, and HCN4 and sodium channels Nav1.5 and Nav1.8, CAV1 becomes a strong candidate susceptibility gene for AF across different ethnic populations.
|
25953654 |
2015 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to assess the associations between polymorphisms on KCNE1, KCNQ1, and KCNH2 with the risk of AF in a Chinese population.
|
26066992 |
2015 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using a linear regression model and adapting a resampling inference, a decrease in longitudinal QTc variance was found to associate with SNPs near KCNH2 (rs10240738) and KCNJ2 (rs8079702) when adjusted for patient age, gender, AF type, and average QTc.
|
24460807 |
2014 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human ether-à-go-go-related gene (hERG) missense mutations N588K and L532P are both associated with atrial fibrillation (AF).
|
24569898 |
2014 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In overall random-effects meta-analyses, association with AF was observed for both SNPs on chromosomes 4q25 [odds ratio (OR), 1.67; 95% CI, 1.50-1.86, P=2×10(-21)] and 16q22 (OR, 1.21; 95% CI, 1.13-1.29, P=1×10(-8)) from genome-wide studies, but not the SNP in KCNH2 from candidate gene studies (P=0.15).
|
22690879 |
2012 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gene therapy with KCNH2-G628S eliminated AF by prolonging atrial action potential duration.
|
20479154 |
2010 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a pair-matched, hospital-based case control study (297 vs 297) conducted in Chinese Hans, we investigated 4 tagging single nucleotide polymorphisms (tSNPs), rs1805120, rs1036145, rs3807375, and rs2968857 in the KCNH2 gene, and determined their association with AF acquired from structural heart diseases.
|
19490382 |
2009 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Patients with mutations in KCNH2 present with higher incidence of AF.
|
18222980 |
2008 |
|
Atrial Fibrillation
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Short QT syndrome and atrial fibrillation caused by mutation in KCNH2.
|
15828882 |
2005 |
|
Atrial Fibrillation
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|