|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
HERG1 knockdown reduced tumor growth and metastasis in athymic mice.
|
31331361 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We provide evidence that hERG1 is expressed in all the BC samples analyzed. hERG1 expression was significantly associated with molecular subtype with the highest expression in Luminal A and the lowest in basal-like tumors (p = 0.001), tumor grading (the highest hERG1 expression in well-moderate differentiated tumors, p = 0.020), estrogen receptors (high hERG1 expression in ER-positive samples, p = 0.008) and Ki67 proliferative index (high hERG1 scoring in samples with low proliferative index, p = 0.038).
|
30002601 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Finally, the <i>in vivo</i> distribution of an Alexa Fluor 750 conjugated scFv-hERG1-Cys was evaluated both in healthy and tumor-bearing nude mice, showing a good tumor-to-organ ratio, ideal for visualizing hERG1-expressing tumor masses <i>in vivo</i>.
|
30405887 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Indeed, hERG1 blockage impairs tumor cell growth both in vitro and in vivo in preclinical mouse model. hERG1-based tumor therapy in humans, however, encounters the major hindrance of the potential cardiotoxicity that many hERG1 blockers exert.
|
26339650 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results reveal a novel mechanism by which hERG1 activation impacts the tumor marker cyclin E2 that is independent of cyclin E1, and suggest a potential therapeutic use for hERG1 channel activators.
|
25596745 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
(i) hERG1 was expressed at high levels in 59% of primary PDAC; (ii) hERG1 blockade decreased PDAC cell growth and migration; (iii) hERG1 was physically and functionally linked to the Epidermal Growth Factor-Receptor pathway; (iv) in transgenic mice, ERG1 was expressed in PanIN lesions, reaching high expression levels in PDAC; (v) PDAC patients whose primary tumour showed high hERG1 expression had a worse prognosis; (vi) the α-hERG1-MoAb could detect PDAC in vivo.
|
25719829 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Allogeneic transplantation of hERG1-expressing cells into nude mice resulted in an increased incidence of tumors.
|
24830940 |
2014 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Indeed, we found that the hERG1 gene was expressed at significant levels by myofibroblasts present in the tumor stroma.
|
24193004 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines.
|
22988594 |
2012 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, up-regulation of hERG1 channel expression has been demonstrated in specific tumors and has been associated with skeletal muscle atrophy in mice.
|
20544339 |
2010 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
HERG1 was expressed in all tumor samples regardless of their stage and in adenomas larger than 0.4 cm, but absent in small adenomas, sigmadiverticulitis specimen and healthy histopathologically negative samples, except for one which developed a tumor recurrence.
|
19577877 |
2010 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The block of the HERG channel might be a potential therapeutic strategy for neuroblastoma and some other tumors with overexpression of the herg gene.
|
17976575 |
2008 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We report here that tumor cell lines preferentially express the herg1 gene and a truncated, N-deleted form that corresponds to herg1b.
|
12431979 |
2003 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
On the whole, these data are the first demonstration of the presence of HERG channels in primary human neoplasias, and could candidate HERG as a potential tool capable of marking cancerous versus hyperplastic endometrial growth.
|
11104572 |
2000 |