Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.310 Biomarker disease CTD_human The high level of KCNJ4 predicted shorter overall survival and was identified as an independent prognostic factor in patients with LADC. siRNA-mediated KCNJ4 silencing impeded LADC cell proliferation, migration, and invasion. 30512237 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.310 Biomarker disease BEFREE The high level of KCNJ4 predicted shorter overall survival and was identified as an independent prognostic factor in patients with LADC. siRNA-mediated KCNJ4 silencing impeded LADC cell proliferation, migration, and invasion. 30512237 2019
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration
0.300 Therapeutic phenotype CTD_human Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway. 18619942 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Therapeutic disease CTD_human Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway. 18619942 2008
CUI: C0596887
Disease: mathematical ability
mathematical ability
0.100 GeneticVariation phenotype GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
CUI: C1853238
Disease: Conotruncal defect
Conotruncal defect
0.100 GeneticVariation disease GWASDB Genome-wide association study of maternal and inherited loci for conotruncal heart defects. 24800985 2014
CONOTRUNCAL HEART MALFORMATIONS (disorder)
0.100 GeneticVariation disease GWASCAT Genome-wide association study of maternal and inherited loci for conotruncal heart defects. 24800985 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE We found that HIR-B expression in the skeletal muscle is increased in NIDDM. 7821730 1994
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE Using the polymerase chain reaction we have recently shown that skeletal muscle of non-diabetic individuals contains predominantly mRNA encoding HIR-A while in skeletal muscle derived from subjects with Type 2 (non-insulin-dependent) diabetes mellitus similar amounts of each mRNA are expressed. 8359580 1993
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE Changes in HIR-A/B expression in the skeletal muscle may thus provide a prognostic criterion for the development of NIDDM. 7681983 1993
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE Results indicate that levels of HIR-B variant are increased in NIDDM patients. 1764093 1991
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE Whereas skeletal muscle of healthy individuals contains exclusively high-affinity HIR-A-encoding RNA, we consistently find low-affinity HIR-B RNA expression in NIDDM muscle tissue at levels similar to HIR-A. 1711209 1991
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Therefore, in this study, we evaluated the expression, clinical correlation, and prognostic value of KCNJ4 in LADC and normal lung tissues according to data from The Cancer Genome Atlas datasets. 30512237 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma. 30512237 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.010 AlteredExpression phenotype BEFREE The high level of KCNJ4 predicted shorter overall survival and was identified as an independent prognostic factor in patients with LADC. siRNA-mediated KCNJ4 silencing impeded LADC cell proliferation, migration, and invasion. 30512237 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE Therefore, in this study, we evaluated the expression, clinical correlation, and prognostic value of KCNJ4 in LADC and normal lung tissues according to data from The Cancer Genome Atlas datasets. 30512237 2019
CUI: C0280255
Disease: stage, endometrial carcinoma
stage, endometrial carcinoma
0.010 GeneticVariation phenotype BEFREE The aim of this study was to explore the role of chemotherapy as adjuvant treatment for early-stage endometrial cancer (EC) with high-intermediate-risk (HIR) factors. 30142124 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.010 Biomarker disease BEFREE These findings indicate that HIR induces shortening and deciliation of kidney primary cilia into the urine via ROS/oxidative stress, suggesting that primary cilia is associated with HIR-induced AKI and that the presence of ciliary proteins in the urine could be a potential indication of kidney injury. 28495528 2017
CUI: C0263504
Disease: Alopecia totalis
Alopecia totalis
0.010 GeneticVariation disease BEFREE Congenital atrichia with papular lesions is a rare, autosomal recessive form of total alopecia and mutations in the hairless (hir) gene have been implicated in this disorder. 11886538 2001
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.010 Biomarker group BEFREE A retrovirus containing part of the human insulin receptor (hIR) gene was constructed by replacing ros sequences in the avian sarcoma virus UR2 with hIR cDNA sequences coding for 46 amino acids of the extracellular domain and the entire transmembrane and cytoplasmic domains of the beta subunit of hIR. 3039503 1987
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue
0.010 Biomarker group BEFREE A retrovirus containing part of the human insulin receptor (hIR) gene was constructed by replacing ros sequences in the avian sarcoma virus UR2 with hIR cDNA sequences coding for 46 amino acids of the extracellular domain and the entire transmembrane and cytoplasmic domains of the beta subunit of hIR. 3039503 1987