Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together, these data show that behavioral sensitivity to cocaine in mice is inversely proportional to the strength of GIRK channel activity in VTA DA neurons and suggest that direct activators of the unique VTA DA neuron GIRK channel subtype (GIRK2/GIRK3 heteromer) could represent a promising therapeutic target for treatment of addiction.<b>SIGNIFICANCE STATEMENT</b> Inhibitory G protein signaling in dopamine (DA) neurons, including that mediated by G protein-gated inwardly rectifying K<sup>+</sup> (GIRK) channels, has been implicated in behavioral sensitivity to cocaine.
|
30837265 |
2019 |
Barbiturate withdrawal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.
|
19759313 |
2009 |
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that variants in KCNJ9 are associated with diabetes in Pimas but do not account for the linkage of 1q with diabetes in this population.
|
11350189 |
2001 |
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that variants in KCNJ9 are associated with diabetes in Pimas but do not account for the linkage of 1q with diabetes in this population.
|
11350189 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The characterization of the KCNJ9 gene should facilitate further studies on the function of the KCNJ9 protein and allow evaluation of the potential role of the locus in Type II diabetes.
|
10913335 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians.
|
11350189 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
KCNJ10-SNP1 is in a strong linkage disquilibrium with SNP14 of the adjacent KCNJ9 locus, which we previously found to be associated with type 2 diabetes.
|
12401729 |
2002 |
Epilepsy, Temporal Lobe
|
0.010 |
Biomarker
|
disease |
BEFREE |
Variations in the AQP4 and the KCNJ10/KCNJ9 region are likely to be associated with TLE, particularly TLE-FS, supporting the suggestion that perturbations of water and K(+) transport are involved in the etiopathogenesis of TLE.
|
19864112 |
2010 |
Hypnotic withdrawal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of Kcnj9, which encodes GIRK3 (Kir3.3), is associated with less severe sedative-hypnotic withdrawal.
|
19759313 |
2009 |
Long QT Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Long QT syndrome type 13 (LQT13) is caused by loss-of-function mutation in the KCNJ5-encoded cardiac G-protein-coupled inward rectifier potassium channel subtype 4 protein.
|
23872692 |
2013 |
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.
|
16109170 |
2005 |