|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Type 2 diabetes risk SNPs in or near KCNJ11 and HHEX were significantly (p < 0.0013), and those in or near CDKN2B, NOTCH2 and MTNR1B were nominally (p < 0.05), associated with decreased liver IR index.
|
21153532 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
|
20054294 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
BEFREE |
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients.
|
21710463 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes.
|
22264780 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
KCNJ11 E23K polymorphism was associated with type 2 diabetes in genetic association studies.
|
22385882 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility.
|
17823772 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
GWASCAT |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
GWASDB |
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
19056611 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabetes (T2D) risk.
|
22187380 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Among women with magnesium intake in the lowest 30% (AA: ≤0.164 g/d; HA: ≤0.185 g/d), 4 SNP signals were strengthened [rs11590362 in claudin 19 (CLDN19), rs823154 in SLC41A1, rs5929706 and rs5930817 in membra; HA: ≥0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk.
|
25733456 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
BEFREE |
Applying our predictive model for the KCNJ11 gene to the Wellcome Trust Case Control Consortium (WTCCC) Type 2 diabetes cohort, we demonstrate how the prediction of phased sequences inferred from GWAS SNP genotype data can be used to facilitate interpretation and identify a probable functional mechanism such as protein changes.
|
22289434 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Association of KCNJ11 rs5219 gene polymorphism with type 2 diabetes mellitus in a population of Syria: a case-control study.
|
31195986 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
|
18162508 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
|
25165692 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
Biomarker
|
disease |
CTD_human |
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
|
16123366 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms in these genes (ABCC8 exon 16-3t/c, exon 18 T/C, KCNJ11 E23K) have been variably associated with type 2 diabetes, but no large ( approximately 2,000 subjects) case-control studies have been performed.
|
12540637 |
2003 |