KDR, kinase insert domain receptor, 3791

N. diseases: 623; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1865871
Disease: HEMANGIOMA, CAPILLARY INFANTILE
HEMANGIOMA, CAPILLARY INFANTILE 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C1865871
Disease: HEMANGIOMA, CAPILLARY INFANTILE
HEMANGIOMA, CAPILLARY INFANTILE 		0.700 Biomarker disease CTD_human
CUI: C1865871
Disease: HEMANGIOMA, CAPILLARY INFANTILE
HEMANGIOMA, CAPILLARY INFANTILE 		0.700 CausalMutation disease CLINVAR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation disease UNIPROT
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.590 CausalMutation disease CGI
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 CausalMutation group CGI
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.400 CausalMutation disease CGI
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.400 GeneticVariation disease UNIPROT
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.360 GeneticVariation disease UNIPROT
CUI: C4016109
Disease: HEMANGIOMA, CAPILLARY INFANTILE, SOMATIC
HEMANGIOMA, CAPILLARY INFANTILE, SOMATIC 		0.300 Biomarker phenotype GENOMICS_ENGLAND
CUI: C0206733
Disease: Strawberry nevus of skin
Strawberry nevus of skin 		0.130 Biomarker disease HPO
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE This protein has characteristics of a tyrosine kinase growth factor receptor and is postulated to be important in human carcinogenesis. 1974168 1990
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 AlteredExpression disease BEFREE We show that KDR mRNA is co-expressed with flt-1 in vascular cells in glioblastoma but not in low-grade glioma. 7525492 1994
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Relatively abundant levels of UFO/AXL and KDR mRNAs were observed in a subset of the melanoma cell lines whereas most of the remaining protein kinases were expressed at similar levels in both normal and transformed melanocytes. 7858416 1994
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE We show that KDR mRNA is co-expressed with flt-1 in vascular cells in glioblastoma but not in low-grade glioma. 7525492 1994
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE We show that KDR mRNA is co-expressed with flt-1 in vascular cells in glioblastoma but not in low-grade glioma. 7525492 1994
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Since flt-1 and KDR are not expressed in endothelial cells in the normal adult brain, the coordinate up-regulation of 2 receptors for VEGF appears to be a critical event which controls tumor angiogenesis. 7525492 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.100 AlteredExpression disease BEFREE We show that KDR mRNA is co-expressed with flt-1 in vascular cells in glioblastoma but not in low-grade glioma. 7525492 1994
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.080 Biomarker disease BEFREE Overexpression of HER-2/neu, a 185-kDa tyrosine kinase growth factor receptor, in human ovarian cancers has been correlated with a poor prognosis for survival of the disease. 7835782 1994
CUI: C1997217
Disease: Low grade glioma
Low grade glioma 		0.010 AlteredExpression disease BEFREE We show that KDR mRNA is co-expressed with flt-1 in vascular cells in glioblastoma but not in low-grade glioma. 7525492 1994
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression group BEFREE Expression of the c-kit tyrosine kinase growth factor receptor has been reported in some breast tumors; however, no data exist concerning expression of its ligand, stem cell factor. 7545433 1995
CUI: C0017638
Disease: Glioma
Glioma 		0.100 Biomarker disease BEFREE To analyze the molecular mechanisms underlying glioma angiogenesis, we studied the expression of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptors VEGFR-1 and VEGFR-2 during normal brain development and glioma-induced angiogenesis. 8586468 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Using reverse-transcriptase polymerase chain reaction (RT-PCR), the expression of VEGF was found in 15/15 human tumour cell lines examined, while the VEGF receptor KDR was detected only in three melanoma cell lines (MeWo and A375, both wild type and metastatic variant). 8554590 1995
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE VEGF, flt, and KDR expression was localized by in situ hybridization and immunohistochemistry in frozen sections of primary tumors from five patients with ovarian carcinoma and from metastases of ovarian carcinoma from three different patients. 7707437 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE KDR and flt1 mRNA were limited to tumor endothelial cells and were more strongly expressed in the hepatic metastases than in the sinusoidal endothelium of the surrounding liver parenchyma. 7535799 1995