KDR, kinase insert domain receptor, 3791

N. diseases: 623; N. variants: 23
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker disease BEFREE According to Dr. Wells A. Messersmith, targeted therapies (ie, VEGFR, EGFR, multitargeted tyrosine kinase inhibitors) play an important role in CRC management, but none of them have been successful in the adjuvant setting (although checkpoint inhibition is now being tested in MSI-high stage III CRC). 31117039 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 AlteredExpression disease BEFREE Thus, we evaluated VEGF, VEGFR-1 and VEGFR-2 expression in ECs of colorectal cancer (CRC) using immunohistochemistry. 30423986 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 GeneticVariation disease BEFREE Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. 29588308 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.600 Biomarker disease BEFREE Lastly, we demonstrated that miR-150-5p inactivated VEGFA/VEGFR2 and the downstream Akt/mTOR signaling pathway in CRC. 30476901 2018