KDR, kinase insert domain receptor, 3791

N. diseases: 623; N. variants: 23
Disease: Tumor Angiogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE [<sup>111</sup>In]In-NODAGA-Z<sub>VEGFR2</sub>-Bp<sub>2</sub> appears to be a promising probe for in vivo noninvasive visualization of tumor angiogenesis in glioblastoma. 30214632 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE In view of the synergistic potential of FGFs and VEGFs in tumor angiogenesis observed in preclinical studies, the FGFR/VEGFR2 dual inhibitor 25a may achieve better clinical benefits. 29775937 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor receptor 2 (VEGFR2) has been proven to play a major role in the regulation of tumor angiogenesis. 28599090 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Moreover, the complex nanoparticles significantly increased the cellular apoptosis and down-regulated the expression of EGFR and VEGFR2 proteins related with cell proliferation and tumor angiogenesis. 28755539 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Real-Time PCR, Western Blot and Immunofluorescence staining showed that plumbagin treatment suppressed expression of angiogenesis pathways (PI3K-Akt, VEGF/KDR and Angiopoietins/Tie2) and angiogenic factors (VEGF, CTGF, ET-1, bFGF),which is associated with tumor angiogenesis in cancer cells and xenograft tumor tissues. 28122355 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. 28194552 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) by vascular endothelial growth factor (VEGF) is a critical step in the signal transduction pathway that initiates tumor angiogenesis. 28621580 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE In this context, besides immunohistological evaluation, molecular ultrasound imaging with BR55, the clinically used VEGFR2-targeted microbubbles, was applied to monitor VEGFR2-positive vessels noninvasively and to assess the therapy effects on tumor angiogenesis. 28938160 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Radiolabeling of VEGF165 with 99mTc to evaluate VEGFR expression in tumor angiogenesis. 28498441 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis. 27878269 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor receptors (VEGFRs) are the major receptors involved in endothelial cell-dependent tumor angiogenesis. 28359326 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. 28919780 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE These findings suggest that isoprenaline stimulate VGEF secretion and subsequently up-regulate the expression of plexin-A1 and VEGFR2 in gastric cancer cells, which form a positive impetus to promote tumor angiogenesis. 29262812 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Although VEGFR-1 is considered as functionally impaired kinase, its decoy characteristics make it an important regulator of VEGFR-mediated signaling, particularly in tumor angiogenesis. 27049304 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Kinase insert domain receptor (KDR) is involved in the regulation of tumor angiogenesis, migration, and vascular permeability. 26081139 2016
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Furthermore, induction of β2M-mediated VEGFR-2/Akt/mTOR phosphorylation and tumor angiogenesis was significantly suppressed by over-expression of DKK-3. 26278164 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Furthermore, in order to disclose the role of miR-497 on angiogenesis, VEGFR2-luc transgenic mice were treated with miR-497 mimic and applied to monitor tumor angiogenesis and growth by in vivo bioluminescent imaging (BLI). 26345385 2015
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Furthermore, administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors, indicating that Hedgehog-driven stroma suppresses tumor growth in part by restraining tumor angiogenesis. 24856585 2014
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis. 24335081 2014
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway. 24241173 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Taken together, our findings suggest that disrupting endocan interaction with VEGFR-2 or VEGF-A could offer a novel rational strategy to inhibit tumor angiogenesis. 23243026 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE In conclusion, the results from current study demonstrate that antagomir-21 can effectively suppress tumor growth and angiogenesis in VEGFR2-luc mouse breast tumor model and bioluminescent imaging can be used as a tool for noninvasively and continuously monitoring tumor angiogenesis in vivo. 23951172 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Further, we show that VEGFR-2 and VEGFR-1 blocking antibodies displayed opposing effects on tumor angiogenesis. 23267058 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Jiedu Xiaozheng Yin, a Chinese herbal formula, inhibits tumor angiogenesis via downregulation of VEGF-A and VEGFR-2 expression in vivo and in vitro. 23254951 2013
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE The signaling transductions mediated by the binding of vascular endothelial growth factor (VEGF) to its receptor KDR (kinase insert domain receptor) is the most important pathway in tumor angiogenesis. 22182247 2012