|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The degree of plaque disruption and expression of TF and HK-II appear to be important vascular factors for AMI onset, and polarized macrophages make a distinct contribution to thrombogenicity and glucose metabolism.
|
26346032 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, KIF2A may serve as a valuable prognostic indicator and promising therapeutic target of LUAD.
|
29427669 |
2018 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, we demonstrate that APC requires interactions with both kinesin-2 and kinesin-1 for this localisation.
|
27272132 |
2016 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
|
28616658 |
2017 |
|
Agyria
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Bardet-Biedl Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cilium formation, maintenance and function depend on intracellular transport systems such as intraflagellar transport (IFT), which is driven by kinesin-2 and IFT-dynein motors and regulated by the Bardet-Biedl syndrome (BBS) cargo-adaptor protein complex, or BBSome.
|
27930654 |
2016 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, multivariate analysis indicated that KIF2A was an independent prognostic for outcome in breast cancer (OR: 16.55, 95% CI: 2.216-123.631, P = 0.006).
|
24950762 |
2014 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kinesin family member 2a (KIF2A), a member of the KIFs, has received attention for its role in carcinogenesis and its prognostic value in several human cancers such as breast cancer, colorectal cancer, and squamous cell carcinoma.
|
29781531 |
2018 |
|
Cancer of Nasopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
These antigens were encoded by 3 novel genes, genes of unknown function (KIAA0445, KIAA1853, KIAA0665, FLJ13942, HSPC213), a proto-oncogene (rab18), candidate tumor suppressor genes (BAP1, PRDM13) and genes encoding a motor protein (kinesin-2), a histone (H2A1.2), the ankyrin residue-rich nasopharyngeal cancer susceptibility protein (NZ16) and the transcription factor TZP, which is homologous to the tumor-associated antigens HCA58 and GLEA2.
|
12800201 |
2003 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Kinesin superfamily protein 2A (KIF2A), an M type nonmotile microtubule depolymerase, has received attention for its role in carcinogenesis and prognostic value in several types of cancer.
|
26070867 |
2015 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Kinesin family protein 2A (KIF2A), an M-type nonmotile microtubule depolymerase, has attracted attention for its role in carcinogenesis and poor prognoses in various human cancers.
|
27773961 |
2016 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The role of KIF2A during breast cancer tumorigenesis and progression was studied.
|
24950762 |
2014 |
|
Carcinogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The abnormal expression and dysfunction of KIF2A are associated with tumorigenesis and the progression of certain human cancer types; however, little is known about the expression and roles of KIF2A in glioma.
|
26707290 |
2016 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Kinesin family member 2a (KIF2A), a member of the KIFs, has received attention for its role in carcinogenesis and its prognostic value in several human cancers such as breast cancer, colorectal cancer, and squamous cell carcinoma.
|
29781531 |
2018 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We hypothesized that aberrant KIF2A and HER2-neu expression might be associated with aggressive behavior of epithelial ovarian cancer (EOC).To address the prognostic implications of KIF2A and HER2-neu in EOC, we assessed protein levels of KIF2A and HER2-neu in 159 ovarian and fallopian tube tissues (111 carcinomas and 48 normal ovary or fallopian tube tissues) by immunohistochemistry (IHC) analysis on tissue microarray and KIF2A mRNA levels in 35 ovarian and fallopian tube tissues (15 carcinomas and 20 normal ovary or fallopian tube tissues) by real-time PCR.We found that significantly higher KIF2A mRNA expression in EOC tumors than that in normal ovary or fallopian tube tissues.
|
26937910 |
2016 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
HK-II is reportedly highly expressed in some human solid carcinomas by many studies.
|
27823965 |
2017 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition to KIF2C, we also found that the related kinesin KIF2A is modestly upregulated in this model system; both proteins are expressed more highly in many lung cancer cell lines compared to normal tissue.
|
24240690 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
The results suggest KIF2A could serve a valuable prognostic indicator in ovarian cancer and provide a rationale for treatment of ovarian cancer by targeting KIF2A via miR-206.
|
30352438 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis of variance revealed that overexpression of KIF2A was an independent prognostic factor for OS.These findings indicate the important role of KIF2A in predicting EOC prognosis.
|
26937910 |
2016 |
|
Chronic gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry of KIF2A was performed on a tissue microarray composed of 461 GC and 65 matched adjacent nontumor tissues removed during surgeries and 18 chronic gastritis, 15 intestinal metaplasia, and 37 low-grade and 62 high-grade intraepithelial neoplasias acquired through gastric endoscopic biopsies.
|
27773961 |
2016 |
|
Classical Lissencephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This report also establishes that KIF2A mutations represent significant causes of classic lissencephaly with microcephaly.
|
27747449 |
2017 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that targeting HK II may be beneficial for patients with colon cancer treated with 5-FU.
|
18772588 |
2008 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both KIF2A mRNA and protein product exhibited CRC tissue-preferred expression, when compared with benign tissues.
|
26070867 |
2015 |
|
Congenital Abnormality
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genetic findings reported by our group and others showed that de novo missense variants in the KIF2A gene underlie malformations of brain development called pachygyria and microcephaly.
|
29077851 |
2018 |
|
Congenital Abnormality
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Recently, KIF2A mutations were identified in cortical malformation syndromes associated with microcephaly.
|
27747449 |
2017 |