KNG1, kininogen 1, 3827

N. diseases: 279; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1860224
Disease: ABLEPHARON-MACROSTOMIA SYNDROME
ABLEPHARON-MACROSTOMIA SYNDROME 		0.010 GeneticVariation disease BEFREE As the vasodilator bradykinin may be involved in acclimatization to altitude, we hypothesized that variants in genes encoding components of this pathway might play a role in AMS susceptibility. 20511677 2010
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Selective reduction of second pain sensations by systemic morphine in humans. 3951883 1986
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. 10543429 1999
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Chronopharmacology of morphine in mice. 16076651 2005
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. 20018876 2010
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice. 10445233 1999
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Mechanism of pain induced by radiocontrast media. 1281941 1992
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms. 29655911 2018
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema 		0.340 Biomarker disease BEFREE Acquired C1 inhibitor (C1-INH) deficiency exposes patients to angioedema recurrences (acquired angioedema [AAE]) mediated by bradykinin pathway activation. 23406939 2013
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema 		0.340 Biomarker disease CTD_human Plasma bradykinin in angio-oedema. 9734886 1998
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema 		0.340 Biomarker disease BEFREE A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). 21905496 2011
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema 		0.340 Biomarker disease BEFREE During remission, cleaved HK was normal in HAE and high in AAE; during attacks it increased in HAE (P = .0008) and remained elevated in AAE. 9129025 1997
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema 		0.340 Biomarker disease BEFREE Acquired angioedema due to C1-inhibitor (C1INH) deficiency (AAE) is caused by secondary C1INH deficiency leading to bradykinin-mediated angioedema episodes. 31397881 2019
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASCAT Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. 20303064 2010
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASDB Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. 22703881 2012
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASDB Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. 20303064 2010
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASDB A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array. 23188048 2013
CUI: C0030605
Disease: Activated Partial Thromboplastin Time measurement
Activated Partial Thromboplastin Time measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. 22703881 2012
CUI: C0333233
Disease: Active Hyperemia
Active Hyperemia 		0.300 Biomarker phenotype CTD_human Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage. 11837250 2002
CUI: C0333240
Disease: Acute edema
Acute edema 		0.010 Biomarker phenotype BEFREE Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). 17418383 2007
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Therapeutic disease CTD_human The role of high-energy phosphate in norepinephrine-induced acute renal failure in the dog. 3015452 1986
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Therapeutic disease CTD_human Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog. 513486 1979
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Therapeutic disease CTD_human The role of high-energy phosphate in norepinephrine-induced acute renal failure in the dog. 3015452 1986
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Therapeutic disease CTD_human Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog. 513486 1979