|
Complex Regional Pain Syndromes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Recently, we developed a bradykinin reporter assay and demonstrated the differing protease activity in Complex Regional Pain Syndrome patients vs. controls.
|
31718985 |
2020 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Bradykinin-potentiating factor isolated from Leiurus quinquestriatus scorpion venom alleviates cardiomyopathy in irradiated rats via remodelling of the RAAS pathway.
|
31664738 |
2020 |
|
Airway Obstruction
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings show that central BK administration sensitizes cough and enhances airway obstruction via a B<sub>2</sub> receptor/TRPV1 and/or TRPA1 channels which are coupled via metabolites of COX and/or 12-LOX enzymes.
|
31170972 |
2019 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that bradykinin receptor inhibition alleviates the vascular dysfunction in a transgenic arcAβ mouse model of cerebral amyloidosis and that fMRI techniques can be used to monitor the treatment response.
|
30890928 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis.
|
30621761 |
2019 |
|
Epilepsy, Temporal Lobe
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High levels of cleaved H-kininogen and free PKal, and low levels of C1-inhibitor (TLE = 188 ± 12 µg/mL) were observed in the serum of TLE patients.
|
31206169 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cytokine array analysis showed that bradykinin increases the production of interleukin (IL)-8 in GBM via B1R.
|
30366000 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
[Corrigendum] Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose‑induced osteoblast dysfunction and hyperglycemia‑induced bone deterioration in mice.
|
30816429 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The goal of this study was to explore the role of bradykinins and bradykinin 1 receptor (B1R) in murine lupus nephritis.
|
30621761 |
2019 |
|
Malaria, Cerebral
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> Our studies raise the possibility that therapeutic targeting of kinin forming enzymes and/or endothelial bradykinin receptors might reduce extent of <i>Pf</i>-iRBC sequestration and help to preserve BBB integrity in cerebral malaria (CM).
|
31058153 |
2019 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the verification tests, Kininogen-1 had a sensitivity of 95.1% and a specificity of 97.1% in SCZ prediction.
|
31346501 |
2019 |
|
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Human hippocampal sclerotic tissues removed after surgery for seizure control, plasma, and serum were used in the following assays: immunostaining for white blood cells in the TLE hippocampus, C-reactive protein in serum, quantification of plasma kallikrein (PKal) and cathepsin B (CatB) activity in serum and plasma, quantification of C1-inhibitor, analysis of high-molecular-weight kininogen (H-kininogen) fragments, and activation of plasma prekallikrein for comparison with healthy controls.
|
31206169 |
2019 |
|
Status Epilepticus
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> The proteomics and ELISA results showed that the protein level of kininogen (KNG) was obviously elevated in both CSF and hippocampus, but not in serum, 5 days after the onset of SE in LiCl-Pilo chronic epilepsy model rats.
|
30804871 |
2019 |
|
Thromboangiitis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
The female Wistar rats were injected with lauric acid via the femoral artery to establish the TAO model, and they were randomly divided into control group (healthy rats), model group (TAO rats) and bradykinin group (TAO rats injected with bradykinin B2 receptor-specific inhibitor).
|
31799689 |
2019 |
|
Peripheral Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In contrast to liraglutide, GLP-1 leftward shifted the concentration relaxation curves for bradykinin in s.c. arteries from patients with peripheral arterial disease, an effect resistant to exendin-(9-39).
|
30403290 |
2019 |
|
Exfoliation Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The concentration of complement factor 3, kininogen-1, antithrombin III and vitamin D-binding protein was increased in all eyes with PEX.
|
30842085 |
2019 |
|
Carcinoid crisis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sudden massive release of serotonin, histamine, kallikrein, and bradykinin is postulated to cause an intraoperative carcinoid crisis.
|
30415870 |
2019 |
|
Diabetic macular edema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis showed that Complement 3 levels in vitreous from BK-injected eyes in rats and clinical DME samples were increased by 6.6-fold (p = 0.039) and 4.3-fold (p = 0.02), compared with their respective controls.
|
31351056 |
2019 |
|
Recurrent seizure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patients with encephalitis, the protein level of KNG in the CSF in the postacute phase was significantly elevated in patients with a recurrent epileptic seizure during a 2-year follow-up than in patients without a recurrent seizure.
|
30804871 |
2019 |
|
Idiopathic angioedema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angioedema can occur in isolation, accompanied by urticaria, or as a feature of anaphylaxis in mast cell-mediated disorders, bradykinin-mediated disorders, as well as in others with unknown mechanisms, such as infections, rare disorders, or idiopathic angioedema.
|
30679975 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cytokine array analysis showed that bradykinin increases the production of interleukin (IL)-8 in GBM via B1R.
|
30366000 |
2019 |
|
Cone-Rod Dystrophy 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore this idea a potent bradykinin B2 receptor antagonist HOE-140 was used in our rat model of SCI and cord pathology.
|
31349925 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that kininogen could contribute to HDM-induced rise in Penh independently of allergic lung inflammation.
|
30358441 |
2019 |
|
Epileptic Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In patients with encephalitis, the protein level of KNG in the CSF in the postacute phase was significantly elevated in patients with a recurrent epileptic seizure during a 2-year follow-up than in patients without a recurrent seizure.
|
30804871 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The responsiveness of the stellate cells to bradykinin was markedly reduced in experimental alcohol-related acute pancreatitis, but they became sensitive to stimulation with trypsin.
|
29424931 |
2018 |