KNG1, kininogen 1, 3827

N. diseases: 279; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010200
Disease: Coughing
Coughing
0.380 Biomarker phenotype BEFREE Our findings show that central BK administration sensitizes cough and enhances airway obstruction via a B<sub>2</sub> receptor/TRPV1 and/or TRPA1 channels which are coupled via metabolites of COX and/or 12-LOX enzymes. 31170972 2019
CUI: C0010200
Disease: Coughing
Coughing
0.380 Biomarker phenotype BEFREE Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways. 28084903 2017
CUI: C0010200
Disease: Coughing
Coughing
0.380 Biomarker phenotype CTD_human Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin. 22693178 2012
CUI: C0010200
Disease: Coughing
Coughing
0.380 Biomarker phenotype BEFREE These results are consistent with the hypothesis that the mechanism of cough is related to the accumulation of bradykinin, substance P, and prostaglandins. 21052031 2011
CUI: C0010200
Disease: Coughing
Coughing
0.380 GeneticVariation phenotype BEFREE We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. 19744011 2009
CUI: C0010200
Disease: Coughing
Coughing
0.380 AlteredExpression phenotype BEFREE The transcriptional activity of the bradykinin B2 receptor promoter is involved in the occurrence of cough, and this new marker may provide a valuable tool to detect patients at risk of developing this side effect of ACE inhibitors. 12522467 2002
CUI: C0010200
Disease: Coughing
Coughing
0.380 GeneticVariation phenotype BEFREE Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. 11699055 2001
CUI: C0010200
Disease: Coughing
Coughing
0.380 AlteredExpression phenotype BEFREE These findings provide further evidence of a link between ACEI-induced cough and I/D polymorphism of the ACE gene and suggest that ACEIs induce cough by modulating the tissue level of bradykinin. 11217909 2001
CUI: C0010200
Disease: Coughing
Coughing
0.380 GeneticVariation phenotype BEFREE Several polymorphisms of the human bradykinin B(2) receptor gene may be involved in ACE inhibitor-related cough. 10904024 2000