|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
We investigated whether in rats with three different forms of experimental hypertension prolonged selective elevation of renal medullary blood flow using local infusion of the vasodilator bradykinin would lower arterial pressure.
|
30334256 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Patients with bradykinin-mediated angiœdema were more frequently women [33 (62%) vs. 44 (42%); P = 0.01], had higher frequency of prior ischemic stroke [12 (23%) vs. 9 (8%); P = 0.01], hypertension [46 (87%) vs. 70 (66%); P = 0.005], were more frequently treated with angiotensin-converting enzyme inhibitor [37 (70%) vs. 28 (26%); P < 0.001] and were more frequently hospitalized in intensive care medicine [ICU; 11 (21%) vs. 5 (5%); P = 0.004].
|
31319000 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the effect of Ang II-induced hypertension on basilar artery responsiveness to BK in the Microminipig (MMPig).
|
28587989 |
2017 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Injection of bradykinin increased blood pressure to a greater extent in "ligated" (<i>n</i> = 10) than "freely perfused" (<i>n</i> = 10) rats.
|
28724548 |
2017 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of the bradykinin receptors genes variants with hypertension: a case-control study and meta-analysis.
|
26362411 |
2016 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Risk of bradykinin B2 receptor -58T/C gene polymorphism on hypertension: A meta-analysis.
|
27007662 |
2016 |
|
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Salt-sensitive inhibition of ENaC activity by bradykinin greatly advances our understanding of the molecular mechanisms that are responsible for shutting down distal tubule sodium reabsorption during volume expanded conditions to avoid salt-sensitive hypertension.
|
24378775 |
2014 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of bradykinin B2 receptor (BDKRB2) gene are reported to be predisposing factors for hypertension.
|
22468762 |
2012 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Markers at the peroxisome proliferative activated receptor gamma coactivator 1α (PPARGC1A) and bradykinin β2 receptor (BDKRB2) genes were nominally associated with greater risk of hypertension, although one marker each at the BDKRB2 and endothelial nitric oxide synthase-3 (NOS3) genes were nominally associated with lower risk.
|
20944660 |
2011 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
In 8907 stable CAD patients from the EUROPA trial, 52 haplotype-tagging single-nucleotide polymorphisms (SNPs) in 12 candidate genes within the RAAS and kallikrein-bradykinin pathways were investigated for association with hypertension (defined as BP ≥160/95 mmHg or use of antihypertensives) and BP response to ACE inhibitors, during a 4-week run-in period.
|
21157371 |
2011 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A meta-analysis of the bradykinin B2 receptor gene --58C/T polymorphism with hypertension.
|
20036225 |
2010 |
|
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Tissue kallikrein and kininogen levels in fetoplacental tissues from normotensive pregnant women and women with pregnancy-induced hypertension.
|
17050061 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequence variation of bradykinin receptors B1 and B2 and association with hypertension.
|
15643125 |
2005 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It was recently reported that a polymorphism of the bradykinin B2 receptor gene (BDKRB2) is a genetic predisposing factor for hypertension and cardiovascular disease.
|
15894833 |
2004 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension.
|
14499231 |
2003 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, subnormal kallikrein-kininogen-kinin concentrations could be the cause of reduced vasodilating influence leading to both clinical and experimental hypertension.
|
6925142 |
1982 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
Effects of prostacyclin on cardiovascular reflexes from the ventricular epicardium of the dog: comparison with the effects of prostaglandin E2.
|
7027322 |
1981 |