|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
|
12813015 |
2003 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ARG1 SNPs and haplotypes were not associated with asthma, but all 4 ARG1 SNPs were associated with the number of positive skin tests (P = .007-.018).
|
16387594 |
2006 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Evidence for association from the four asthma cohorts was combined, and SNPs from ARG1 were significantly associated with BDR.
|
18617639 |
2008 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evidence for association from the four asthma cohorts was combined, and SNPs from ARG1 were significantly associated with BDR.
|
18617639 |
2008 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among atopic children living in high-ozone communities, those carrying the ARG1 haplotype had reduced asthma risk (OR per haplotype copy, 0.12; 95% CI, 0.04-0.43; P(heterogeneity) across atopy/ozone categories = .008).
|
19281908 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Among atopic children living in high-ozone communities, those carrying the ARG1 haplotype had reduced asthma risk (OR per haplotype copy, 0.12; 95% CI, 0.04-0.43; P(heterogeneity) across atopy/ozone categories = .008).
|
19281908 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
|
19800904 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations between haplotype-tagging polymorphisms in arginase 1 (n=3) and arginase 2 (n=8) and asthma, asthma severity, acute response to bronchodilators and chronic response to inhaled corticosteroids were analyzed.
|
20124949 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To identify cis-acting haplotypes in the ARG1 locus that are associated with BDR in patients with asthma and regulate gene expression in vitro.
|
20851928 |
2011 |
|
Asthma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
DNA methylation in ARG1 and ARG2 is associated with FeNO in children with asthma and suggests a possible role for epigenetic regulation of nitric oxide production.
|
21512169 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GMDR analyses revealed that rs7216389 in ORMDL3 and rs3756780 in ARG1 might interact for a risk of asthma.
|
22472724 |
2012 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We show here that T(h)2 cell-mediated inflammation in murine asthma models induces the expression of some markers of alternatively activated macrophage such as arginase 1 and resistin-like molecule-α in iDCs by a mechanism depending on the intrinsic expression of STAT6.
|
24150243 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of ARG1 SNPs revealed that rs2781666 G/T genotype, T allele and C-T haplotype (rs60389358 and rs2781666) were associated with susceptibility to asthma.
|
30381539 |
2018 |