KPNA3, karyopherin subunit alpha 3, 3839

N. diseases: 20; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 GeneticVariation disease LHGDN The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. 15882913 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. 15882913 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 GeneticVariation disease BEFREE The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. 15882913 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease LHGDN The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. 16644122 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. 16644122 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 GeneticVariation disease BEFREE The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. 16644122 2006
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE KPNA3 and RANBP5 control the nuclear import of the influenza virus. 18552348 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. 22960338 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 Biomarker disease PSYGENET Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. 22960338 2012
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASDB Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASCAT Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 Biomarker group BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		0.010 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0243010
Disease: Viral Encephalitis
Viral Encephalitis 		0.010 Biomarker group BEFREE These results suggest that JEV NS5 inhibits the induction of type I IFN by targeting KPNA3 and KPNA4.<b>IMPORTANCE</b> JEV is the major cause of viral encephalitis in South and Southeast Asia, with high mortality. 28179530 2017
CUI: C4277690
Disease: Ciliopathies
Ciliopathies 		0.010 GeneticVariation disease BEFREE Using a panel of skeletal dysplasias genes, including 11 related to SRP, we identified biallelic mutations in IFT122 ([c.3184G>C];[c.3228dupG;c.3231_3233delCAT]) in a fetus with a typical phenotype of SRP-IV, finally confirmed that this phenotype is a ciliopathy and adding to the list of ciliopathies with major skeletal involvement. 28370949 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 AlteredExpression disease BEFREE The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. 29250154 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 AlteredExpression disease BEFREE The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. 29250154 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 AlteredExpression disease BEFREE Increased expression of DLEU1 and KPNA3 was observed in human CRC tissues. 30098595 2018