KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE [(18)F]-FLT PET to predict early response to neoadjuvant therapy in KRAS wild-type rectal cancer: a pilot study. 25899481 2015
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial. 26162609 2015
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE We evaluated the tumor response and survival according to the KRAS oncogene status in locally advanced rectal cancer. 26252300 2015
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 AlteredExpression disease BEFREE Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status. 26831663 2016
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy. 27020587 2016
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE KRAS mutation status analyses were performed in 199 tumor samples from 47 patients with rectal cancer. 27064574 2016
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE Locally advanced rectal cancers with simultaneous occurrence of KRAS mutation and high VEGF expression show invasive characteristics. 27184911 2016
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE KRAS mt status may affect the prognosis of early rectal cancer, as this is linked with distant recurrence. 28314302 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer. 28801584 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE Carriers of the homozygous variant genotype TT for rs712 in KRAS gene were associated with a decreased risk of rectal cancer (odds ratio (OR) = 0.65, 95% confidence intervals (CI) 0.43-1.00, P = 0.05) while individuals with colon cancer carrying the heterozygous GT genotype showed a longer overall survival (OS) (P = 0.04). 29048575 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE Neoadjuvant radiotherapy combined with capecitabine and sorafenib in patients with advanced KRAS-mutated rectal cancer: A phase I/II trial (SAKK 41/08). 29241084 2018
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE DKI metrics with whole-tumor volume histogram analysis is associated with KRAS mutations, and thus may be useful for predicting the KRAS status of rectal cancers for guiding targeted therapy. 30637861 2019
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE KRAS status has no difference between colon cancer and rectal cancer. 30917791 2019
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 GeneticVariation disease BEFREE KLF5 was significantly associated with the presence of KRAS mutations, and KLF5 was an independent poor response predictor of CRT in rectal cancer. 31388510 2019
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma
0.100 Biomarker disease BEFREE Characterizing MRI features of rectal cancers with different KRAS status. 31727020 2019