KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Disease: NOONAN SYNDROME 3 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR K-RasV14I recapitulates Noonan syndrome in mice. 25359213 2014
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations. 24803665 2014
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease MGD K-RasV14I recapitulates Noonan syndrome in mice. 25359213 2014
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND The RASopathies. 23875798 2013
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Noonan syndrome: comparing mutation-positive with mutation-negative dutch patients. 23885229 2013
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND KRAS gene mutations in Noonan syndrome familial cases cluster in the vicinity of the switch II region of the G-domain: report of another family with metopic craniosynostosis. 22488932 2012
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Spectrum of mutations in Noonan syndrome and their correlation with phenotypes. 21784453 2011
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR KRAS mutation detection in paired frozen and Formalin-Fixed Paraffin-Embedded (FFPE) colorectal cancer tissues. 21686179 2011
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND Noonan syndrome and clinically related disorders. 21396583 2011
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. 19396835 2009
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. 19396835 2009
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. 17468812 2007
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. 17468812 2007
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction. 16987887 2006
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Germline KRAS mutations cause Noonan syndrome. 16474405 2006
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease UNIPROT Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. 16773572 2006
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 CausalMutation disease CLINVAR Germline KRAS mutations cause Noonan syndrome. 16474405 2006
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease CTD_human
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C1860991
Disease: NOONAN SYNDROME 3
NOONAN SYNDROME 3 		0.900 GeneticVariation disease CLINVAR