KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Forced overexpression of H19 attenuated miR-193b-mediated inhibition on multiple driver oncogenes (EGFR, KRAS, PTEN and IGF1R) and MAPK1 gene, thus triggered EMT and stem cell transformation in HCC. 31705929 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Recent studies suggest that wild-type KRAS and HRAS isoforms could majorly contribute to HCC progression and sorafenib resistance. 30685691 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE These results demonstrate a novel microprotein repressor of the KRAS pathway for the first time and provide new insights into the regulatory mechanisms of oncogenic signaling and HCC therapy. 31240521 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Hepatitis C virus (HCV) NS3 protein possesses protease and helicase activities and is considered an oncoprotein in virus-derived hepatocellular carcinoma. 31462559 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE KRAS mutation was more frequent in RCC than in LCC, and associated with a poor prognosis in LCC patients, but not in RCC patients. 30917791 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE K19<sup>+</sup> HCC had TERT promoter mutations less frequently than K19<sup>-</sup> HCC (31% versus 59%; P = 0.022), and lacked alterations in KRAS and IDH1. 31017316 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE Analysis of the KRAS gene showed only a G12C variation in one large cell carcinoma (LCC) patient, whereas variants were not found in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) cases. 30048458 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE To explore inhibitory effects of genome-specific, chemically synthesized siRNAs (small interference RNA) against NS3 gene of hepatitis C virus (HCV) 1a genotype in stable Huh-7 (human hepatoma) cells as well as against viral replication in serum-inoculated Huh-7 cells. 28870347 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation. 28283039 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma susceptibility. 26535719 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinoma. 24724096 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE No mutations were found in codons 12 and 61 of K-Ras or codons 12, 13 and 61 of the N-Ras and H-Ras genes in any of the HCCs or corresponding non-malignant tissues. 23266750 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE We were not able to identify a correlation between KRAS and benefit from erlotinib-based therapy, as all but one HCC patient had KRAS wild type gene status. 22210086 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 AlteredExpression disease BEFREE The unusual finding on downregulation of Ras expression in primary HCC tumors in the present study together with tumor heterogeneity with respect to Ras-mediated signaling events prompts a new role of the wild type K-Ras as a possible growth suppressor and a stochastic model for progression of hepatic cancer. 21175807 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE These results supported the view that HCV NS3 protein plays a transforming role and provided some clues to elucidate the carcinogenesis mechanism of HCV-related hepatocellular carcinoma. 17928924 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b. 17763321 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 AlteredExpression disease BEFREE Mutations of BRAF and KRAS were evaluated in 25 hepatocellular carcinomas (HCC) and in 69 cholangiocarcinomas (CC) by direct DNA sequencing analyses after microdissection. 12692057 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE Identification of hepatitis C virus (HCV) subtype 1b strains that are highly, or only weakly, associated with hepatocellular carcinoma on the basis of the secondary structure of an amino-terminal portion of the HCV NS3 protein. 12843009 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease BEFREE In the present study, we analyzed sequence diversity of the NS3 protein of HCV and its possible correlation with HCC. 12363018 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease CTD_human K- ras -2 mutations were found in 6 of 18 (33%) examined VC-associated HCCs and in 3 cases of adjacent non-neoplastic liver tissue. 11286481 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker disease CTD_human K-ras-2 mutations were found in five of 12 (42%) examined HCCs and in three cases of adjacent non-neoplastic liver tissue (25%). 11563603 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE K-ras-2 mutations were found in five of 12 (42%) examined HCCs and in three cases of adjacent non-neoplastic liver tissue (25%). 11563603 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE K- ras -2 mutations were found in 6 of 18 (33%) examined VC-associated HCCs and in 3 cases of adjacent non-neoplastic liver tissue. 11286481 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation disease BEFREE In liver tumors induced by vinyl chloride, specific mutational patterns were found in the Ki-ras gene in human ASL, in the Ha-ras gene in hepatocellular carcinoma (HCC) in rats, and in the p53 gene in human and rat ASL. 10767618 2000