Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Forced overexpression of H19 attenuated miR-193b-mediated inhibition on multiple driver oncogenes (EGFR, KRAS, PTEN and IGF1R) and MAPK1 gene, thus triggered EMT and stem cell transformation in HCC.
|
31705929 |
2020 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest that wild-type KRAS and HRAS isoforms could majorly contribute to HCC progression and sorafenib resistance.
|
30685691 |
2019 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results demonstrate a novel microprotein repressor of the KRAS pathway for the first time and provide new insights into the regulatory mechanisms of oncogenic signaling and HCC therapy.
|
31240521 |
2019 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus (HCV) NS3 protein possesses protease and helicase activities and is considered an oncoprotein in virus-derived hepatocellular carcinoma.
|
31462559 |
2019 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
KRAS mutation was more frequent in RCC than in LCC, and associated with a poor prognosis in LCC patients, but not in RCC patients.
|
30917791 |
2019 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
K19<sup>+</sup> HCC had TERT promoter mutations less frequently than K19<sup>-</sup> HCC (31% versus 59%; P = 0.022), and lacked alterations in KRAS and IDH1.
|
31017316 |
2019 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the KRAS gene showed only a G12C variation in one large cell carcinoma (LCC) patient, whereas variants were not found in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) cases.
|
30048458 |
2018 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To explore inhibitory effects of genome-specific, chemically synthesized siRNAs (small interference RNA) against NS3 gene of hepatitis C virus (HCV) 1a genotype in stable Huh-7 (human hepatoma) cells as well as against viral replication in serum-inoculated Huh-7 cells.
|
28870347 |
2017 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation.
|
28283039 |
2017 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma susceptibility.
|
26535719 |
2015 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinoma.
|
24724096 |
2014 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No mutations were found in codons 12 and 61 of K-Ras or codons 12, 13 and 61 of the N-Ras and H-Ras genes in any of the HCCs or corresponding non-malignant tissues.
|
23266750 |
2013 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We were not able to identify a correlation between KRAS and benefit from erlotinib-based therapy, as all but one HCC patient had KRAS wild type gene status.
|
22210086 |
2012 |
Liver carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The unusual finding on downregulation of Ras expression in primary HCC tumors in the present study together with tumor heterogeneity with respect to Ras-mediated signaling events prompts a new role of the wild type K-Ras as a possible growth suppressor and a stochastic model for progression of hepatic cancer.
|
21175807 |
2011 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results supported the view that HCV NS3 protein plays a transforming role and provided some clues to elucidate the carcinogenesis mechanism of HCV-related hepatocellular carcinoma.
|
17928924 |
2007 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b.
|
17763321 |
2007 |
Liver carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Mutations of BRAF and KRAS were evaluated in 25 hepatocellular carcinomas (HCC) and in 69 cholangiocarcinomas (CC) by direct DNA sequencing analyses after microdissection.
|
12692057 |
2003 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification of hepatitis C virus (HCV) subtype 1b strains that are highly, or only weakly, associated with hepatocellular carcinoma on the basis of the secondary structure of an amino-terminal portion of the HCV NS3 protein.
|
12843009 |
2003 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we analyzed sequence diversity of the NS3 protein of HCV and its possible correlation with HCC.
|
12363018 |
2002 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
CTD_human |
K- ras -2 mutations were found in 6 of 18 (33%) examined VC-associated HCCs and in 3 cases of adjacent non-neoplastic liver tissue.
|
11286481 |
2001 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
CTD_human |
K-ras-2 mutations were found in five of 12 (42%) examined HCCs and in three cases of adjacent non-neoplastic liver tissue (25%).
|
11563603 |
2001 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
K-ras-2 mutations were found in five of 12 (42%) examined HCCs and in three cases of adjacent non-neoplastic liver tissue (25%).
|
11563603 |
2001 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
K- ras -2 mutations were found in 6 of 18 (33%) examined VC-associated HCCs and in 3 cases of adjacent non-neoplastic liver tissue.
|
11286481 |
2001 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In liver tumors induced by vinyl chloride, specific mutational patterns were found in the Ki-ras gene in human ASL, in the Ha-ras gene in hepatocellular carcinoma (HCC) in rats, and in the p53 gene in human and rat ASL.
|
10767618 |
2000 |