|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our present findings expounded a novel signal cascade employing miR-154-3p/487-3p and RHOA to fine-tune thyroid cancer cell proliferation and apoptosis.
|
31820783 |
2020 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our present findings expounded a novel signal cascade employing miR-154-3p/487-3p and RHOA to fine-tune thyroid cancer cell proliferation and apoptosis.
|
31820783 |
2020 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our present findings expounded a novel signal cascade employing miR-154-3p/487-3p and RHOA to fine-tune thyroid cancer cell proliferation and apoptosis.
|
31820783 |
2020 |
|
Atrioventricular Block
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disruption of RHOA-ROCK Signaling Results in Atrioventricular Block and Disturbed Development of the Putative Atrioventricular Node.
|
30412368 |
2019 |
|
Cardiomyopathy, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Administration of valsartan reversed the expression profile of RhoA, ROCK and MYL in ACM.
|
31777538 |
2019 |
|
Escherichia coli Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Pathway enrichment analysis showed that down-regulated Ras homolog gene family member A (RHOA) was enriched in pathogenic Escherichia coli infection.
|
30155678 |
2019 |
|
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of RhoA and ROCK were elevated with downregulation of MYL resulting in heart failure.
|
31777538 |
2019 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, SMAD2, EGFR, AKT1, RHOA and GAS5 might be associated with the curative effect of HQDG on hepatitis B cirrhosis patients.
|
30155678 |
2019 |
|
Portal Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-26b mimics played a role in the treatment of rats with cirrhotic portal hypertension by targeting hENT1 to inhibit the RhoA/ROCK-1 signaling pathway.
|
30840291 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, a few in vivo experiments have been successfully conducted to demonstrate the potential value of RhoA/ROCK pathway inhibition in the treatment of OA.
|
31632513 |
2019 |
|
Allergic asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both SHP2 and Ras homolog family member A (RhoA) kinase were robustly activated in the airway eosinophils of children with allergic asthma and of a mouse model with allergic airway inflammation.
|
31361966 |
2019 |
|
Conduction disorder of the heart
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RHOA is expressed in the atrioventricular node (AVN) and altered expression of RHOA results in atrioventricular (AV) conduction disorders in mice.
|
30412368 |
2019 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In the model of gecko tail amputation, the protein levels of gecko MIF (gMIF) have been determined to be significantly increased in the nerve cells of the spinal cord in association with the recruitment of macrophages to the lesion site. gMIF has been shown to interact with the CD74 receptor to promote the migration of macrophages through activation of Ras homolog gene family member A and to trigger inflammatory responses through MAPK signaling pathways.
|
31689136 |
2019 |
|
Adenocarcinoma, intestinal type
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study showed that intestinal-type adenocarcinoma with anastomosing glands represents a genetically distinct group of tumors with the frequent presence of RHOA mutations and CLDN18-ARHGAP fusions, which are thought to be specific to diffuse-type gastric cancers.
|
30425335 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, SNS-032 repressed the c-Myc-dependent transcription of RhoA gene, and thereby lowered the RhoA GTPase activity and actin polymerization, and subsequently inhibited cell motility and liver metastasis.
|
31526394 |
2019 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |
|
Malformations of Cortical Development, Group II
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Restoration of the RhoA protein level partially rescued the neuronal migration defects in the GR-knockdown and GR-overexpressing neurons, indicating that RhoA played a major role in GR-mediated neuronal migration.
|
31176306 |
2019 |
|
ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we show that postzygotic inactivating mutations of RHOA cause a neuroectodermal syndrome combining linear hypopigmentation, alopecia, apparently asymptomatic leukoencephalopathy, and facial, ocular, dental and acral anomalies.
|
31570889 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cell division control protein 42 homolog (CDC42) and Ras homolog gene family member A (RhoA) were the therapy targets of YQYYHTQY recipe on T2DM.
|
29654829 |
2018 |
|
Encephalomyelitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using mice with a T-cell specific deletion of the RhoA gene (RhoA<sup>fl/fl</sup>LckCre<sup>+</sup>), we investigated the role of RhoA in T-cell development, functionality, and encephalitogenic potential in EAE.
|
29904389 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with the control group, the mRNA and protein levels of RhoA and ROCK2 were higher in the FGR group but lower in the Taurine group (p < .05).
|
28412885 |
2018 |
|
Myopia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings provided evidence for a mechanical strain-induced RhoA/ROCK2 pathway that may contribute to myopia scleral remodeling.
|
30029249 |
2018 |
|
Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of constitutively active and dominant-negative isoforms of RHOA revealed that it acts downstream of VANGL2 to regulate proliferation and maintenance of TPCs in human RMS.
|
29499154 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis.
|
29580806 |
2018 |