|
Malignant neoplasm of stomach
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
|
31771969 |
2020 |
|
Malignant neoplasm of stomach
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, NORAD's expression was positively correlated with RhoA and ROCK1 expressions in GC based on The Cancer Genome Atlas (TCGA) database.
|
31115002 |
2019 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
BEFREE |
Moreover, an abundance of studies show RHOA association with Lauren classification diffuse subtype, in addition to poorly differentiated GC.
|
31156701 |
2019 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
BEFREE |
Expressions of Ras Homolog Gene Family, Member A (RhoA) and Cyclooxygenase-2 (COX-2) Proteins in Early Gastric Cancer and Their Role in the Development of Gastric Cancer.
|
28624843 |
2017 |
|
Malignant neoplasm of stomach
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
CDH1 alterations, but not RHOA mutations, were associated with shorter survival times of patients, which might account for the aggressive clinical course of early-onset gastric cancer.
|
28522256 |
2017 |
|
Malignant neoplasm of stomach
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Here, we show: i) differences in RHOA expression patterns, and its pathway activity, between Asian and Caucasian GC tumors; ii) in vitro and in vivo perturbed RHOA expression inhibits GC cell growth in high RHOA-expressing cell lines; iii) inverse correlation between RHOA and RHOB expression; and iv) an innovative small molecule design strategy for RHOA inhibitors.
|
27806312 |
2016 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
BEFREE |
We performed a thorough review of 87 diffuse-type gastric cancers, including 22 RHOA-mutated and 65 RHOA wild-type gastric cancers.
|
25823974 |
2016 |
|
Malignant neoplasm of stomach
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Recently, the comprehensive molecular characterization of GC subtypes revealed mutations in the small GTPase RHOA as a hallmark of diffuse-type GC.
|
27566106 |
2016 |
|
Malignant neoplasm of stomach
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was found in the overall survival between RHOA mutant and wildtype GCs.
|
26251521 |
2016 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
CTD_human |
Comparison of mutational profiles for the major gastric cancer subtypes showed that RHOA mutations occur specifically in DGCs, the majority of which were histopathologically characterized by the presence of poorly differentiated adenocarcinomas together with more differentiated components in the gastric mucosa.
|
24816255 |
2014 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
CTD_human |
The top perturbed pathways in gastric cancer included adherens junction and focal adhesion, in which RHOA and other mutated genes we identified participate as key players.
|
24816253 |
2014 |
|
Malignant neoplasm of stomach
|
0.390 |
Biomarker
|
disease |
CTD_human |
In the present study, we have analyzed the expression status of the RhoA protein in human gastric cancer cells and tissues and investigated the possible involvement of RhoA in regulating the malignant phenotype of gastric cancer cells.
|
15448013 |
2004 |