Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study confirms that variants at CFH, C3, and ARMS2 confer significant risks for GA due to AMD.
|
19823576 |
2009 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gene variants in CFH, ARMS2, and HTRA1 contribute to AMD in the Chinese population.
|
22618592 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, two previously suspected SNPs in ARMS2, including rs2736911, the SNP having the largest number of studies in our meta-analyses; and rs3793917, the SNP with the largest sample size, were not significantly associated with AMD (both p's > 0.12).
|
24013816 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69).
|
29335418 |
2018 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with exudative AMD (P = 0.011), but not with PCV (P = 0.077).
|
22491416 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association between the genotype of ARMS2 rs10490924 polymorphism and IVR treatment responsiveness in patients with neovascular AMD.
|
28002601 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variants R38X and the indel are less likely to play a pathogenic role in AMD by changing the level of ARMS2 transcripts.
|
23942973 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association with risk alleles of the age-related maculopathy susceptibility 2 (ARMS2) gene was significantly stronger in sporadic AMD patients compared to familial cases (p = 0.017 for all AMD stages and p = 0.003 for advanced AMD, respectively).
|
27258093 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The final model included the following independent variables: age, smoking history, family history of AMD (first-degree member), phenotype based on a modified Age-Related Eye Disease Study simple scale score, and genetic variants CFH Y402H and ARMS2 A69S.
|
21825180 |
2011 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
|
18162041 |
2007 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
We demonstrate, by evaluating 45 tag SNPs spanning HTRA1, PLEKHA1, and predicted gene LOC387715/ARMS2, that rs10490924 SNP alone, or a variant in strong linkage disequilibrium, can explain the bulk of association between the 10q26 chromosomal region and AMD.
|
17884985 |
2007 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To survey the prevalence of reticular pseudodrusen in late age-related macular degeneration (AMD) using multiple imaging methods, and to investigate the association between reticular pseudodrusen and polymorphisms in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes.
|
23111182 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Seventeen single nucleotide polymorphisms (SNPs) in known AMD risk-associated genes including CFH (rs800292, rs3766404, rs1061170, rs2274700 and rs393955), HTRA1 (rs11200638), CFHR1-5 (rs10922153, rs16840639, rs6667243, and rs1853883), LOC387715/ARMS2 (rs3793917 and rs10490924), C3 (rs2230199 and rs1047286), C2 (rs547154), CFB (rs641153) and F13B (rs6003) were examined.
|
23582991 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No differential methylation site reached genome-wide significance; however, when epigenetic changes in and around known GWAS-defined AMD risk loci were explored, we found small but significant DNA methylation differences in the blood of neovascular AMD patients near age-related maculopathy susceptibility 2 (ARMS2), a top-ranked GWAS locus preferentially associated with neovascular AMD.
|
26067391 |
2015 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Early identification of individuals with genetic risk variants CFH p.Y402H and ARMS2 p.A69S is clinically important for the definition of AMD status.
|
22706242 |
2012 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
The findings suggest that CFH and ARMS2 share a common pathway in the pathogenesis of AMD.
|
22133792 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular AMD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011).
|
24865191 |
2014 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of neovascular age-related macular degeneration in the Thai population.
|
28703135 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH rs800292" genes_norm="3075;5362">I62V rs800292, ARMS2 rs10490924" genes_norm="387715">A69S rs10490924.
|
30596689 |
2018 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.
|
21122828 |
2011 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In our Southern California population, the ARMS2 (rs10490924) and CFH (rs1061170) genes were significantly but independently associated with AMD.
|
23302509 |
2013 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 2067 Caucasian subjects from the Age-Related Eye Disease Study cohort for commonly associated AMD SNPs, including those in CFH (rs1061170, rs1410996, and rs3766404), ARMS2 (rs10490924), and C3 (rs2230199) using either a Sequenom MassARRAY MALDI-TOF mass spectrometer or using Taqman genotyping reagents.
|
27420564 |
2017 |