|
Congenital disorder of glycosylation, type 2C
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Leukocyte adhesion deficiency type II (LAD II) is a rare disorder characterized by recurrent infections, persistent leukocytosis, and severe mental and growth retardation.
|
10571012 |
1999 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed that LAD and LVEDD (both p < 0.001), rather than the C allele of the CYP11B2 gene (p= 0.107) were significant predictors for AF.
|
21846681 |
2011 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models.
|
24349426 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32 arbitrary units) or high (> 32 units) GADA titre, 620 subjects with Type 2 diabetes [from the Non-Insulin Requiring Autoimmune Diabetes (NIRAD) study cohort of 5330 subjects] in addition to 551 consecutive cases of Type 1 diabetes and 545 normoglycaemic subjects were analysed for the rs12255372 and rs7903146 polymorphisms of the TCF7L2 gene using Taqman.
|
20546291 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?
|
19120276 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Two hundred and fifty patients identified as LADA, divided into two subgroups with low (< or = 32 arbitrary units) or high (> 32 units) GADA titre, 620 subjects with Type 2 diabetes [from the Non-Insulin Requiring Autoimmune Diabetes (NIRAD) study cohort of 5330 subjects] in addition to 551 consecutive cases of Type 1 diabetes and 545 normoglycaemic subjects were analysed for the rs12255372 and rs7903146 polymorphisms of the TCF7L2 gene using Taqman.
|
20546291 |
2010 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models.
|
24349426 |
2013 |
|
Hypertensive disease
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In multilocus haplotype analysis, the association between frequencies of the haplotypes and AF risk was showed in AGT gene (rs7539020-rs3789678), compared 'TT' haplotype with the common 'TC' haplotype, adjusted for age, gender, LVEF, LVEDD, LAD and frequency of hypertension and diabetes.
|
25723521 |
2015 |
|
Cerebrovascular accident
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Cardiac output (CO), maximal pressure in the LV (Pmax in-LV), stroke volume (SV), left ventricular ejection fraction (LVEF), diastolic durations, heart rate, and arterial systemic pressure were evaluated with conductance catheters for the following periods: basal (before SMR), SMR with patent LAD, and SMR with occluded LAD.
|
29327562 |
2018 |
|
Diabetes, Autoimmune
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We previously demonstrated the presence of two different populations among adult-onset autoimmune diabetes (latent autoimmume diabetes of adults; LADA) having high or low titre of antibodies to glutamic acid decarboxylase (GADA).
|
20546291 |
2010 |
|
Diabetes, Autoimmune
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Ninety-eight patients with type 1 diabetes (median age, 35 years; range, 9-89 years and 51 patients with latent autoimmune diabetes (LADA; median age, 48 years; range, 19-79 years) were compared with 113 healthy control patients (median age, 35 years; range, 19-65 years) to study the importance of MICA-microsatellite polymorphism and HLA-DR-DQ as genetic risk factors for diabetes.
|
12941547 |
2003 |
|
ST segment elevation myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The first randomized controlled trial in patients with CTOs recently reported that patients with ST elevation myocardial infarction (STEMI) and a CTO in the non-culprit vessel showed an improvement in ejection fraction in patients undergoing CTO PCI of the LAD, but not other vessels.
|
28315181 |
2017 |
|
ST segment elevation myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Multivariable analysis showed that presentation with STEMI (odds ratio [OR]: 2.71, P = 0.001), troponin I >50 µg/L (OR: 1.02, P = 0.005), and SCAD involvement of the LAD (OR: 2.5, P = 0.002) were independent predictors of baseline LVEF <50%.
|
28218398 |
2017 |
|
Autoimmune Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This report clearly illustrates the differences in terms of autoimmunity (prevalence and titer of GAD and IA2 antibodies) and HLA class II genotype between patients with LADA and those with juvenile type 1 diabetes.
|
17395515 |
2007 |
|
Autoimmune Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
There were significant associations of risk T allel of the analyzed polymorphism with all studied autoimmune diseases (GDOR = 1.34, p = 7.02e-03; MSOR = 1.36, p = 2.17e-02; LADA - OR = 3.36, p = 8.73e-07).
|
31733941 |
2020 |
|
Multiple Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This study showed an association of rs1990760 polymorphism in the IFIH1 gene in the development of GD, LADA diabetes and MS within the Polish population.
|
31733941 |
2020 |
|
Graves Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to analyse a possible association of three autoimmune disabilities - Multiple sclerosis (MS), LADA diabetes and Graves' disease (GD) with single nucleotide polymorphism (SNP; rs1990760) in the IF IH1 gene (also known as a melanoma differentiation-associated protein 5 - MDA5) within the Polish population.
|
31733941 |
2020 |
|
Skin Ulcer
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Here we present four Indian patients with LAD-I from three unrelated families initially diagnosed as PG due to chronic recurrent skin ulcerations requiring steroids and antibiotics for healing, associated with atrophic scar formation.
|
25876705 |
2015 |
|
Varicosity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CPF was supplied by multiple branches from the LAD and RCA, and formed a complex common varicosity with multiple drainage channels to the pulmonary artery.
|
30019821 |
2018 |
|
Peripheral Vascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Independent predictors of MACE were cardiogenic shock (HR 2.54; 95%CI 1.75-3.70; p<0.001), ST in LAD (HR 1.76; 95%CI 1.32-2.35; p<0.001) prior CVA/TIA (HR 1.68; 95%CI 1.08-2.62; p=0.020), peripheral vascular disease (HR 1.55; 95%CI 1.00-2.39; p=0.046), multivessel disease (HR 1.53; 95%CI 1.12-2.08; p=0.007), and final TIMI flow 2-3 (HR 0.54; 95% CI 0.34-0.85; p=0.009).
|
31475906 |
2019 |
|
Chronic acquired lymphedema
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Truncular venous malformations and acquired functional or anatomical venous occlusions (or sub-occlusions) can be the cause of secondary lymphedema and even the cause of primary lymphedema when they are associated with lymphatic malformations (lymphangiodysplasia - LAD I, lymphadenodysplasia - LAD II, or a combination of both) in pediatric patients.
|
30234251 |
2017 |
|
Lymphatic Abnormalities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Truncular venous malformations and acquired functional or anatomical venous occlusions (or sub-occlusions) can be the cause of secondary lymphedema and even the cause of primary lymphedema when they are associated with lymphatic malformations (lymphangiodysplasia - LAD I, lymphadenodysplasia - LAD II, or a combination of both) in pediatric patients.
|
30234251 |
2017 |
|
Single vessel disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of single-vessel disease (odd ratio [OR] = 2.490; 95% confidential interval [95% CI] = 1.376-4.506; P = .002), total LAD occlusion (OR = 1.897; 95% CI = 1.024-3.515; P = .041), absence of previous angina (OR = 1.930; 95% CI = 1.035-3.600; P = .037), time between myocardial infraction (MI) and coronary angiography more than 12 h (OR = 1.970; 95% CI = 1.044-3.719; P = .035), GFR less than 60 mL/min (OR = 2.933; 95% CI = 1.564-5.503; P = .001), and ferritin levels (P = .0003) were all higher in the aneurysm group compared with those in the control group.
|
30170438 |
2018 |
|
Multiple disability
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to analyse a possible association of three autoimmune disabilities - Multiple sclerosis (MS), LADA diabetes and Graves' disease (GD) with single nucleotide polymorphism (SNP; rs1990760) in the IF IH1 gene (also known as a melanoma differentiation-associated protein 5 - MDA5) within the Polish population.
|
31733941 |
2020 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Additionally, Cox proportional analysis indicated that the miR‑150GA genotype was associated with survival in patients with ischemic stroke [adjusted hazard ratio (HR), 2.063; 95% CI, 1.142-3.727; P=0.017] and with the LAD subgroup [adjusted HR, 3.021; 95% CI, 1.345-6.785; P=0.008].
|
27246008 |
2016 |