|
Immunoglobulin A deficiency (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable region gene segments (IGHV) in 20 of these, in order to identify a possible molecular basis of the defect.
|
1356100 |
1992 |
|
Lymphoma, Follicular
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient.
|
1495966 |
1992 |
|
Multiple Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region.
|
1672695 |
1991 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias.
|
1700749 |
1990 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias.
|
1700749 |
1990 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.
|
2503826 |
1989 |
|
Plasmacytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sequences required for the function of the mouse V1 immunoglobulin heavy chain variable-region (VH) promoter were identified by transient transfection of the normal and mutated promoters into plasmacytoma cells.
|
3118372 |
1987 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We have previously shown that the cytogenetic breakpoints of one t(14;14)(q11;q32) chromosome and two inv(14)(q11;q32) chromosomes in T-cell tumors from AT and non-AT patients join the T-cell receptor alpha chain locus, at chromosome band 14q11, with a region(s) at 14q32 centromeric of the immunoglobulin heavy chain variable region (VH) gene IGHV.
|
3194418 |
1988 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
The immunoglobulins secreted by these cell lines reacted variably with a panel of anti-idiotypic antibodies, indicating that the tumor was heterogeneous; however, one antibody, 4D6, reacted strongly with the product of all the heterohybridomas. cDNA for the immunoglobulin heavy chain variable-region genes expressed in these heterohybridomas was cloned and sequenced.
|
3496601 |
1987 |
|
Rheumatoid Arthritis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.
|
7751018 |
1995 |
|
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma.
|
7950918 |
1994 |
|
Multiple Sclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin heavy chain variable region polymorphisms and multiple sclerosis susceptibility.
|
8496340 |
1993 |
|
Multiple Sclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.
|
8568530 |
1995 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia.
|
8751479 |
1996 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia.
|
8751479 |
1996 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No evidence for linkage between the VH genes and IDDM could be obtained from haplotype-sharing analysis among the 133 diabetic sib pairs.
|
8755935 |
1996 |
|
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.
|
8892685 |
1996 |
|
Lymphoma
|
0.050 |
GeneticVariation
|
group |
BEFREE |
To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three cases of lymphoma.
|
9111510 |
1997 |
|
Adult Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three cases of lymphoma.
|
9111510 |
1997 |
|
Childhood Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three cases of lymphoma.
|
9111510 |
1997 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These results demonstrate that pneumococcal vaccination changes the pattern of B cell VH gene expression and support the concept that aberrant VH3 expression may translate into a poor antipneumococcal response in the setting of HIV infection.
|
10762563 |
2000 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
A polymerase chain reaction ELISA was used to determine the proportion of peripheral IgG, IgA, and IgM CD19-positive B cells expressing 6 immunoglobulin heavy-chain variable region (VH) subgroups before and 7 days after pneumococcal vaccination of 12 HIV-infected and 12 HIV-uninfected subjects.
|
10762563 |
2000 |
|
Rheumatoid Arthritis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A relationship between these secondary V(H) gene rearrangements and the autoimmunity characteristic of RA should be considered.
|
11034605 |
2000 |
|
Autoimmune Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A relationship between these secondary V(H) gene rearrangements and the autoimmunity characteristic of RA should be considered.
|
11034605 |
2000 |
|
Lymphoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Immunoglobulin heavy chain variable region family expression in primary cutaneous follicle centre cell lymphomas.
|
11298550 |
2001 |