LAMC1, laminin subunit gamma 1, 3915

N. diseases: 57; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 AlteredExpression disease BEFREE Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in CRC tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). 28039327 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease GWASDB Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.410 GeneticVariation disease UNIPROT
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease BEFREE miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. 26052614 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 AlteredExpression disease BEFREE Silencing of LAMC1 significantly inhibited cell migration and invasion in cancer cells, and LAMC1 was upregulated in PCa. miR-29s acted as tumor suppressors, contributing to cancer cell migration and invasion and directly targeting laminin signaling. 24820027 2014
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.320 Biomarker disease CTD_human Global analysis of differentially expressed genes in androgen-independent prostate cancer. 17199135 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 Biomarker group CTD_human Global analysis of differentially expressed genes in androgen-independent prostate cancer. 17199135 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 AlteredExpression group LHGDN Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration. 15967115 2005
CUI: C0003493
Disease: Aortic Diseases
Aortic Diseases 		0.300 Biomarker group CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153 2014
CUI: C0024796
Disease: Marfan Syndrome
Marfan Syndrome 		0.300 Biomarker disease CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153 2014
CUI: C4721845
Disease: Marfan Syndrome, Type I
Marfan Syndrome, Type I 		0.300 Biomarker disease CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153 2014
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.100 GeneticVariation group GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.100 GeneticVariation group GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.100 GeneticVariation group GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0346629
Disease: Malignant neoplasm of large intestine
Malignant neoplasm of large intestine 		0.100 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
CUI: C0346629
Disease: Malignant neoplasm of large intestine
Malignant neoplasm of large intestine 		0.100 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019