Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo, cG7-MICA recruited NK cells to the tumor site and improved the anti-tumor efficacy of sorafenib. cG7-MICA also activated NK cells to release interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α), and it increased the CD107a expression on the surface of the NK cells in vitro.
|
30778749 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Followingstimulation, expressions of CD107a and intracellular IFN-γ were elevated in tumor CMV positive patients while the TNF-α secretion was decreased.
|
31522446 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In PDX-bearing mice, intravenous administration of mAb 14-25-9 increased degranulation (CD107a expression) of intratumorally injected patient autologous or allogeneic NK cells, as well as inhibited tumor growth when treated long term.
|
31164357 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, expression of Lamp1 by tumor infiltrating CD8<sup>+</sup> T cells was elevated, indicating enhanced release of cytotoxic granules.
|
28875329 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In light of this, we evaluated the impact of induced regulatory T (iTreg) cells on the efficacy of tumour cell killing redirected by ImmTAC and demonstrated down-regulation of T-cell proliferation and expression of CD25, CD107a, Granzyme B and Perforin by ImmTAC-redirected T cells.
|
29791021 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results revealed that combination of DC vaccine and 5-FU reduced number of MDSCs (3%) and also tumor growth rate(10%)(p<0.05) and increased mice survival (70%) and increased CD8+ /CD107a+ T cells (25%).
|
29512369 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The Vγ2Vδ2 cells had higher levels of CD107a and perforin and increased tumor cytotoxicity.
|
28239463 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The LAMP1 expression levels were significantly different between different T status (P<0.001), TNM stages (P<0.01) and degrees of tumor histological differentiation (P<0.001).
|
28687162 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Local depletion of tumor-associated Tregs with photodynamic therapy (PDT) inhibited tumor growth, which was likely due to the altered tumor immune microenvironment that was characterized by increased infiltration of CD8+ effector T cells and the expression of IFN-γ and CD107a, which is a cytolytic granule exocytosis marker in tumor tissues.
|
28537894 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
T cells were transduced with a lentivirus encoding the PSCA-CAR and evaluated for cytokine production (paired Student's t-test), proliferation (paired Student's t-test), CD107a expression (paired Student's t-test) and target cell killing in vitro and tumor growth and survival in vivo (Log-rank test comparing Kaplan-Meier survival curves).
|
24438073 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upon encounter, with matched tumor lines, antigen reactive T cells rapidly lose CD62L expression and this was associated with the acquisition of CD107a.
|
21829468 |
2011 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These regions contained representative tumor-related genes, such as the FGF8 and NPM3 genes at 10q24.32, and the LAMP1 gene at 13q34, which have been reported in connection with various tumors.
|
20428766 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, vaccination with irRC/AdV/GM or irRC/SeV/GM cells induced significantly enhanced recruitment of the cytolytic effectors of CD107a(+)CD8(+) T cells and CD107a(+) natural killer cells into tumors compared with those induced by their respective controls (P < 0.05).
|
18957055 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All mice were protected against challenge with TC-1 cells and most animals remained tumour-free in therapeutic-immunisation experiments with these cells, in contrast to immunisation with unfused E7GGG and the fusion with the lysosome-associated membrane protein 1 (Sig/E7GGG/LAMP-1).
|
15386741 |
2004 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Northern analysis revealed that P2B/LAMP-1 is widely expressed in normal murine tissues and tumor cell lines.
|
2676155 |
1989 |