Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Higher rates of low ERCC1 (35.6 vs. 20.3%, P = 0.0105), RRM1 (23.3 vs. 13.0%, P = 0.0437), STMN1 (72.2 vs. 42.8%, P = 0.0000) and high VEGFR2 (34.4 vs. 18.8%, P = 0.0078) mRNA expression were found in EGFR-mutated tumors, suggesting possible benefit from platinum, gemcitabine, taxanes or VEGFR2 inhibitors.
|
29948972 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated a positive correlation between mRNA and protein expression of p27 and expression of key metastatic markers, vimentin, snail-2, β-catenin and stathmin-1 (STMN1) in patient tumors.
|
30992462 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, the intratumor T-regulatory and MDSC levels significantly correlated with progression-free and overall survival, the PD-1<sup>+</sup>/LAG-3<sup>+</sup>/TIM-3<sup>+</sup> CD4<sup>+</sup> tumor-infiltrating lymphocytes correlated with overall survival.
|
31078776 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the association of high Stathmin 1 expression with poor survival was significant even for sub-group analyses of different tumor types, ethnicities, methods used to calculate HRs, detected methods, and analysis types.
|
30278466 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer.
|
29374725 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High tumor expression of STMN1 was significantly associated with the presence of metastases (P=0.028), Enneking surgical stage (P=0.030), tumor response to chemotherapy (P=0.011), and the site of tumor origin (P=0.023).
|
30169496 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor formation assay in nude mice showed that tumor formation was delayed after Stathmin downregulation, with a reduction in both tumor formation rate and tumor growth velocity.
|
29880026 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of STMN1 resulted in reduced proliferation and invasion of cells and tumor growth and metastasis <i>in vivo</i> Furthermore, miR-34a downregulated STMN1 by directly binding to its 3'-UTR.
|
29025958 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with STMN1-overexpressing tumors had a higher 3‑year lymphatic metastatic recurrence rate (P=0.024).
|
29251330 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that silencing STMN alleviates the resistance to taxol and collectively contributes to induce the dysfunction of multiple signals and down regulate the malignancy of tumors; thus, STMN is a promising target in treating refractory tumors.
|
28589243 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High STMN1 immunoexpression was significantly associated with tumor depth, lymph node metastasis, lymphatic invasion and venous invasion.
|
28350065 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
STMN1 expression was significantly associated with prognosis and tumour differentiation in ESCC, indicating that STMN1 expression is an independent prognostic factor for ESCC and could be a potential biomarker.
|
29039594 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We confirmed: (i) positive association of anterior gradient protein 2 homolog (AGR2) and periostin (POSTN) and negative association of annexin A1 (ANXA1) with estrogen receptor status; (ii) positive association of stathmin (STMN1), cofilin-1 (COF1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1) and negative associations of thrombospondin-2 (TSP2) and POSTN levels with tumor grade; and (iii) positive association of POSTN, alpha-actinin-4 (ACTN4) and STMN1 with lymph node status.
|
28216224 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed significant up-regulation of STMN1 mRNA expression in recurrent tumors in comparison with primary tumors (p<0.05).
|
28622584 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was concluded that the high expression of STMN1 contributed to tumor proliferation and malignant transformation in the patients with IPMN.
|
28454324 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that patients with OSCC tumors showing high expression of stathmin 1 might have poor therapeutic effects and worse clinical outcomes in OSCC treated with Doc-containing regimen.
|
26590596 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we found that STMN1 was significantly elevated in HSCC and its expression level was correlated with poor differentiation (P<0.001), clinical stage (P<0.001), large tumor size (P=0.001) and lymph node metastasis (P=0.008).
|
27878293 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
VBL is an attractive alternative to the treatment of Taxol-resistant tumors with high expression of Op18/stathmin.
|
28259950 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stathmin has been investigated as a tumor biomarker because it appear to be associated with tumorigenesis; however, the effect of stathmin in lung adenocarcinoma (LAC) remains poorly understood.
|
27494889 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No correlation between Stathmin expression and age, gender and tumor extent of resection was found (p>0.05).
|
28625575 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Reports show that the stathmin gene may have a close relationship with tumor chemotherapeutic sensitivity.
|
26802649 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis.
|
26815505 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In H-RasV12 transformed cells, p27kip1 suppressed cell proliferation and tumor growth via two distinct mechanisms: 1) inhibition of CDK activity and 2) impairment of MT-destabilizing activity of stathmin.
|
27579539 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This T<sub>3</sub>-mediated suppression of STMN1 supports the theory that T<sub>3</sub> plays an inhibitory role in HCC tumor growth, and suggests that the lack of normal THR function leads to elevated STMN1 expression and malignant growth.
|
27934948 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo.
|
27349455 |
2016 |