Lactate dehydrogenase deficiency type A
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.
|
27604308 |
2016 |
Lactate dehydrogenase deficiency type A
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining.
|
1953713 |
1991 |
Lactate dehydrogenase deficiency type A
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Estimation of the gene frequency of lactate dehydrogenase subunit deficiencies.
|
6517049 |
1984 |
Lactate dehydrogenase deficiency type A
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
Lactate dehydrogenase deficiency type A
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
Myoglobinuria
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
|
21332213 |
2011 |
Myoglobinuria
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, HK1, PKLR, and LDHA expression correlated positively with PC progression.
|
31689601 |
2020 |
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
The targeting of glycolytic enzymes such as PKM2 and LDHA represents a promising therapeutic approach for the treatment of pancreatic cancer.
|
31527446 |
2019 |
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
CTD_human |
MTOR inhibitor-based combination therapies for pancreatic cancer.
|
29384525 |
2018 |
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings highlight p53 status in pancreatic cancer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response.
|
26113084 |
2015 |
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that c-Myc and LDHA are concomitantly overexpressed in pancreatic cancer cell lines and clinical specimens. c-Myc overexpression and LDHA overexpression were correlated with TNM stage and tumor size and indicated poor prognosis in patients with pancreatic cancer.
|
26021472 |
2015 |
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.
|
24634381 |
2014 |
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We found a negative correlation between KLF4 and LDHA expression in pancreatic cancer cells and tissues and that their expression was associated with clinicopathologic features of pancreatic cancer.
|
24947925 |
2014 |
Malignant neoplasm of pancreas
|
0.380 |
Biomarker
|
disease |
BEFREE |
Taken together, our study revealed the oncogenic role of LDHA in pancreatic cancer and suggested that LDHA might be a potential therapeutic target.
|
23404405 |
2013 |
Malignant neoplasm of pancreas
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers.
|
23523103 |
2013 |
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
BEFREE |
In <i>in vivo</i> experiments, tumor growth was markedly inhibited by LDH-A silencing in a xenograft model of LUAD.
|
30509961 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.
|
29756998 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
Mental Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Further results proved that AS modulated energy metabolism in depression through the inhibition of the expression of pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK-1) and lactate dehydrogenase A (LDHA).
|
30894817 |
2019 |
Pancreatic Neoplasm
|
0.310 |
Biomarker
|
disease |
CTD_human |
MTOR inhibitor-based combination therapies for pancreatic cancer.
|
29384525 |
2018 |
Pancreatic Neoplasm
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Expression of KLF4 and lactate dehydrogenase A (LDHA) in 70 primary pancreatic tumors and 10 normal pancreatic tissue specimens was measured.
|
24947925 |
2014 |
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Furthermore, the mRNA expression levels of GLUT1, PGK1, and LDHA were increased in MDD patients in a depressive state compared to healthy control subjects.
|
23333658 |
2013 |
Major Depressive Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects.
|
23333658 |
2013 |
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects.
|
23333658 |
2013 |