LDHA, lactate dehydrogenase A, 3939

N. diseases: 185; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Lactate dehydrogenase deficiency type A
0.600 Biomarker disease GENOMICS_ENGLAND Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes. 27604308 2016
Lactate dehydrogenase deficiency type A
0.600 Biomarker disease GENOMICS_ENGLAND Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining. 1953713 1991
Lactate dehydrogenase deficiency type A
0.600 Biomarker disease GENOMICS_ENGLAND Estimation of the gene frequency of lactate dehydrogenase subunit deficiencies. 6517049 1984
Lactate dehydrogenase deficiency type A
0.600 GermlineCausalMutation disease ORPHANET
Lactate dehydrogenase deficiency type A
0.600 Biomarker disease CTD_human
CUI: C0027080
Disease: Myoglobinuria
Myoglobinuria
0.400 Biomarker phenotype CTD_human Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. 21332213 2011
CUI: C0027080
Disease: Myoglobinuria
Myoglobinuria
0.400 Biomarker phenotype HPO
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 AlteredExpression disease BEFREE Furthermore, HK1, PKLR, and LDHA expression correlated positively with PC progression. 31689601 2020
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 Biomarker disease BEFREE The targeting of glycolytic enzymes such as PKM2 and LDHA represents a promising therapeutic approach for the treatment of pancreatic cancer. 31527446 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 Biomarker disease CTD_human MTOR inhibitor-based combination therapies for pancreatic cancer. 29384525 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 Biomarker disease BEFREE Taken together, our findings highlight p53 status in pancreatic cancer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response. 26113084 2015
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 AlteredExpression disease BEFREE In this study, we found that c-Myc and LDHA are concomitantly overexpressed in pancreatic cancer cell lines and clinical specimens. c-Myc overexpression and LDHA overexpression were correlated with TNM stage and tumor size and indicated poor prognosis in patients with pancreatic cancer. 26021472 2015
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 AlteredExpression disease BEFREE FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. 24634381 2014
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 AlteredExpression disease BEFREE We found a negative correlation between KLF4 and LDHA expression in pancreatic cancer cells and tissues and that their expression was associated with clinicopathologic features of pancreatic cancer. 24947925 2014
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 Biomarker disease BEFREE Taken together, our study revealed the oncogenic role of LDHA in pancreatic cancer and suggested that LDHA might be a potential therapeutic target. 23404405 2013
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.380 AlteredExpression disease BEFREE Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers. 23523103 2013
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.320 Biomarker disease BEFREE In <i>in vivo</i> experiments, tumor growth was markedly inhibited by LDH-A silencing in a xenograft model of LUAD. 30509961 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.320 AlteredExpression disease BEFREE LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC. 29756998 2018
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.320 Biomarker disease CTD_human c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. 27602772 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.310 AlteredExpression disease BEFREE Further results proved that AS modulated energy metabolism in depression through the inhibition of the expression of pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK-1) and lactate dehydrogenase A (LDHA). 30894817 2019
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.310 Biomarker disease CTD_human MTOR inhibitor-based combination therapies for pancreatic cancer. 29384525 2018
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.310 AlteredExpression disease BEFREE Expression of KLF4 and lactate dehydrogenase A (LDHA) in 70 primary pancreatic tumors and 10 normal pancreatic tissue specimens was measured. 24947925 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.310 Biomarker disease PSYGENET Furthermore, the mRNA expression levels of GLUT1, PGK1, and LDHA were increased in MDD patients in a depressive state compared to healthy control subjects. 23333658 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 AlteredExpression disease BEFREE We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects. 23333658 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker disease PSYGENET We also found increased expression of HIF-1α and LDHA mRNA in MDD patients in a remissive state, whereas the mRNA expression levels of other genes in a remissive state were comparable to those in healthy control subjects. 23333658 2013