LDLR, low density lipoprotein receptor, 3949

N. diseases: 336; N. variants: 1434
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease BEFREE Given that PCSK9 degrades the LDL receptor (LDLR) and prevents the removal of LDL from the blood into the liver, in the present study we examined the effect of hepatic steatosis on LDLR expression and circulating LDL cholesterol levels. 31004037 2019
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2015
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease BEFREE Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. 21690266 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease BEFREE Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. 21321189 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. 21690266 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 AlteredExpression disease BEFREE Primarily in female mice, hepatic cholesterol accumulation induced by SCP-2 overexpression was associated with increased levels of LDL-receptor, HDL-receptor scavenger receptor-B1 (SR-B1) (as well as PDZK1 and/or membrane-associated protein 17 kDa), SCP-2, liver fatty acid binding protein (L-FABP), and 3alpha-hydroxysteroid dehydrogenase, without alteration of other proteins involved in cholesterol uptake (caveolin), esterification (ACAT2), efflux (ATP binding cassette A-1 receptor, ABCG5/8, and apolipoprotein A1), or oxidation/transport of bile salts (cholesterol 7alpha-hydroxylase, sterol 27alpha-hydroxylase, Na(+)/taurocholate cotransporter, Oatp1a1, and Oatp1a4). 19289417 2009
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. 19073773 2009
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. 18172117 2008
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. 17720268 2007
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet. 16835442 2006
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology. 16368783 2006
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. 15472122 2004
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. 15207278 2004
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. 12847522 2003
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease MGD Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. 9326295 1997
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.640 Biomarker disease HPO