|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis.
|
31748470 |
2020 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease.
|
31748469 |
2020 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We aimed to establish a HFpEF model associated with hypercholesterolemia and type 2 diabetes mellitus by feeding a high-sucrose/high-fat (HSHF) diet to C57BL/6J low-density lipoprotein receptor (LDLr)<sup>-/-</sup> mice.
|
31064116 |
2019 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Activation of PCSK9 can thus decrease the expression of LDLR in the liver and inhibit LDL uptake, which leads to hypercholesterolaemia.
|
28549755 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
PCSK9, through promoting lysosomal degradation of hepatic low-density lipoprotein (LDL) receptor, can decrease the clearance of plasma LDLs, leading to hypercholesterolaemia and consequent atherosclerotic plaque formation.
|
31236571 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrated that BBR treatment reduced plasma LDL-C, TC and TG in LDLR wildtype (WT) mice fed a high fat and high cholesterol diet and it only lowered TG in LDLR WT mice fed a normal chow diet.
|
31666640 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
PCSK9 regulates LDL receptor degradation and plays key roles in hypercholesterolemia and related cardiovascular diseases.
|
31593224 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
To evaluate whether TRAF5 affects neointima formation, TRAF5-/-LDLR-/- and TRAF5+/+LDLR-/- mice consuming a high cholesterol diet (HCD) received wire-induced injury of the carotid artery.
|
31437850 |
2019 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Their levels, correlated inversely to LDL-R expression and directly to LDL-C, seem to play a central role in hypercholesterolaemia in NS.
|
31157893 |
2019 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The ACAT-2 and CYP7A1 mRNA expression were significantly decreased in HC diet supplemented with STG, while the mRNA levels of LDLR were markedly increased.
|
30937311 |
2019 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction.
|
31061510 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We propose the following classification: familial hypercholesterolemia syndrome integrated by (1) heterozygous familial hypercholesterolemia: patients with clinically definite FH and a functional mutation in one allele of the LDLR, ApoB:100, and PCSK9 genes; (2) homozygous familial hypercholesterolemia: mutations affect both alleles; (3) polygenic familial hypercholesterolemia: patients with clinically definite FH but no mutations associated with FH are found (to be distinguished from non-familial, multifactorial hypercholesterolemia); (4) familial hypercholesterolemia combined with hypertriglyceridemia: a subgroup of familial combined hyperlipidaemia patients fulfilling clinically definite FH with associated hypertriglyceridemia.
|
31238171 |
2019 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of elevated cholesterol and the function of LDLr in neural precursor cells (NPC) isolated from adult C57BL/6JRj mice in vitro.
|
31767163 |
2019 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Familial hypercholesterolemia (FH) is the most appropriate model for understanding the effects of excess LDL-C because affected individuals have inherently high levels of circulating LDL-C. To clarify the effects of hypercholesterolemia on cerebral small vessel disease (SVD), we investigated cerebrovascular damage in detail due to elevated LDL-C using high resolution brain magnetic resonance imaging (MRI) in patients with FH.
|
30880296 |
2019 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Novel compound heterozygous mutations in low density lipoprotein receptor gene causes a severe phenotype in a Chinese hypercholesterolemia family.
|
30112042 |
2018 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
However, adropin over expression does not prevent hypercholesterolemia resulting from a high cholesterol diet and/or LDL receptor mutations.
|
29331507 |
2018 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was a comparison of aortic valve calcium score (AVCS) between patients with hypercholesterolemia and genetic diagnosis of familial hypercholesterolemia with low-density lipoprotein receptor gene mutation (LDLR-M group), versus patients with hypercholesterolemia without LDLR gene mutation (LDLR-WT group).
|
30592719 |
2018 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The results suggested that this strategy could be applied for evaluating potential bioactive compounds inhibiting the interaction of PCSK9/LDLR and this strategy could accelerate the discovery of new drug candidates for the treatment of PCSK9-mediated hypercholesterolemia.
|
30235833 |
2018 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the heterozygous Ldlr KO hamsters on a short-term HCHF diet also had overt hypercholesterolemia, which could be effectively ameliorated with several lipid-lowering drugs.
|
29289533 |
2018 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Therefore, enhancing LDLR expression represents a potent treatment strategy for hypercholesterolemia.
|
30385871 |
2018 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7.
|
30243490 |
2018 |
|
Hypercholesterolemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish.
|
29187523 |
2018 |
|
Hypercholesterolemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We recruited 49 nonfamilial hypercholesterolemia genetic hypercholesterolemia families (294 participants) and calculated cholesterol gene scores, derived from single nucleotide variants in SORT1, APOB, ABCG8, APOE and LDLR and lipoprotein(a) plasma concentration.
|
28919240 |
2018 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Hypercholesterolemia in hypothyroidism is mainly due to a reduction in low-density lipoprotein (LDL) receptor activity, this accompanied by concomitant diminishing control by triiodothyronine (T3) of sterol regulatory element-binding protein 2 (SREBP-2), which modulates cholesterol biosynthesis by regulating rate-limit degrading enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) activity.
|
30233497 |
2018 |
|
Hypercholesterolemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Therefore, strategies that enhance the protein level of LDLR provide an attractive therapeutic target for the treatment of hypercholesterolemia.
|
30025252 |
2018 |