Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In experimental animals and humans that are responsive to leptin, suppression of leptin production under conditions of negative energy balance (e.g., fasting) can exaggerate both hypothermia and behavioral depression.
|
17275915 |
2007 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the LEP gene appears to be an important genetic determinant for susceptibility to depression in the Indian population (OR=1.4913, 95% CI=1.0334-2.1522; P=.04).
|
19382181 |
2009 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse.
|
23251447 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression.
|
22408745 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our results suggest an involvement of leptin in antidepressant action and cognitive function in depression with genetic polymorphisms in the leptin gene, decreased leptin gene expression and leptin deficiency in serum being risk factors for resistance to antidepressant therapy in depressed patients.
|
23026132 |
2013 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours.
|
22932068 |
2013 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest an involvement of leptin in antidepressant action and cognitive function in depression with genetic polymorphisms in the leptin gene, decreased leptin gene expression and leptin deficiency in serum being risk factors for resistance to antidepressant therapy in depressed patients.
|
23026132 |
2013 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?
|
25629253 |
2015 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, a biological link between leptin resistance and depression has been proposed.
|
25629253 |
2015 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression was associated with a decrease and increase in leptin respectively in normal-overweight and obese men and women diabetes patients.
|
28197877 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The relationship between serum serotonin concentration and depression is well known, but there are no enough data regarding the serum change of leptin and adiponectin.
|
28224268 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this first study, behavioral analyses of an unpredictable stress model dealing with the actions of a sub-chronic administration of orexin-A (ORX-A) and the anti-hunger neuropeptide, i.e., leptin (LEP) within the hypothalamic suprachiasmatic (SCH) nucleus, were conducted on the valuable hibernating rodent (hamster; Mesocricetus auratus) model noted for its distinct depression and anxiety states.
|
26993304 |
2017 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance.
|
29190710 |
2017 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that decrease in BDNF by the activated NLRP3 inflammasomes in astrocytes is the key pathological event of the depressive-like behaviors induced by SD, while the combined treatment with fluoxetine and leptin improves therapeutic outcome for the depression induced by SD.
|
30666218 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin may influence these mechanisms and consequently constitute a possible target for novel therapeutic approaches to the treatment of depression.
|
30367065 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we consider the links between co-morbid metabolic syndrome and depression, focusing on biomarkers including leptin and ghrelin in combination with assessing gut microbiota composition, as a potential tool to help identify individual differences in depressed population.
|
30405455 |
2018 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Small clinical studies suggest depression is associated with alterations in adiponectin and leptin, adipocyte-derived secretory proteins involved in metabolic regulation; however, longitudinal data on these association are lacking.
|
30005278 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that leptin has antidepressant-like effects in an inflammatory model of depression with the contribution, at least partial, of dopamine receptors.
|
30949073 |
2019 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results affirm the need to implement depression screening and targeted treatment interventions for patient subgroups at highest risk of untreated symptoms, such as men with LEP.
|
31667737 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression in underweight BMI groups of both genders was associated with a decrease in serum leptin and an increase in cortisol.
|
31347937 |
2019 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Plasma BDNF (pBDNF) and blood leptin levels were obtained along with a 17-item Hamilton Depression Scale rating (HDRS-17) score at every visit.
|
31465895 |
2019 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher plasma leptin and lower C-peptide levels are associated with depression: A cross-sectional study.
|
30236760 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Data of patients with a current depressive and/or anxiety disorder came from the Netherlands Study of Depression and Anxiety, a large, multi-site naturalistic cohort study (n = 1460).Thirty-six biomarkers (e.g. leptin, brain-derived neurotrophic factor, tryptophan) were measured, as well as sociodemographic and clinical characteristics.
|
29860945 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depression scores correlated with serum leptin (r = 0.29, [95%CI: 0.14-0.42]; r = 0.32, [95%CI: 0.18-0.45]) and FLI (r = 0.30, [95%CI: 0.15-0.43]; r = 0.32, [95%CI: 0.17-0.45]; P < 0.0001 for all).
|
31404477 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The findings indicate that P-leptin levels are associated with depressive symptom severity in young women; however, the association is linked to other factors, which challenges its usefulness as a biomarker for depression in clinical psychiatry.
|
30562581 |
2019 |