|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have thus been able to confirm a tight relationship between serum leptin and body mass but have found no evidence for genetic linkage of the ob gene markers to morbid obesity in a population considered to represent a genetic isolate and to be an ideal model for studies of complex disorders.
|
9150718 |
1997 |
|
Obesity, Morbid
|
0.400 |
Therapeutic
|
disease |
CTD_human |
A leptin missense mutation associated with hypogonadism and morbid obesity.
|
9500540 |
1998 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The massive obesity caused in rodents by the disruption of the leptin-receptor signal through genetic defects at the level of either leptin (OB) or leptin receptor (OB-R) has raised the question of the relevance of these genes to morbid obesity in humans.
|
9545018 |
1998 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In rodents, homozygous mutations in genes encoding leptin or the leptin receptor cause early-onset morbid obesity, hyperphagia and reduced energy expenditure.
|
9537324 |
1998 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
CTD_human |
A leptin missense mutation associated with hypogonadism and morbid obesity.
|
9500540 |
1998 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism.
|
10523015 |
1999 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the leptin 25CAG allele may be linked to morbid obesity in this population.
|
11140377 |
2000 |
|
Obesity, Morbid
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In order to examine the involvement of leptin in the ossification of spinal ligaments (OSL), the present study examined (i) serum levels of leptin and insulin in OSL patients and controls, (ii) serum leptin levels in children of OSL females with severe obesity, (iii) the expression of leptin receptor mRNA in human spinal ligaments, and (iv) effects of leptin on cultured human ligament cells.
|
10673363 |
2000 |
|
Obesity, Morbid
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to investigate the regulation of the gene expression of leptin in subcutaneous adipose tissue biopsies in morbid obesity before and after biliopancreatic diversion (BPD).
|
12033286 |
2002 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, mutations in the gene's encoding leptin and its cognate receptor cause severe obesity in humans.
|
12481551 |
2002 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The only situation in which obesity does not parallel leptin values is the rare case of morbid obesity due to leptin deficiency caused by missense mutation of the leptin gene.
|
12519870 |
2003 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
CTD_human |
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We document here that leptin replacement therapy in leptin-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and noningestive behavior.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the physiological role of leptin in the control of meal size and the response to satiety signals, and to identify brain areas mediating this effect, we studied Koletsky (fa(k)/fa(k)) rats, which develop severe obesity due to the genetic absence of leptin receptors.
|
15711637 |
2005 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rare mutations in the leptin (LEP) gene cause severe obesity.
|
15937081 |
2005 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We and others have identified several single gene defects that disrupt the molecules in the leptin-melanocortin pathway causing severe obesity in humans.
|
17122358 |
2006 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin is an adipocyte-secreted hormone, and deficiency of either leptin or its receptor has been shown to cause morbid obesity in animals and in humans.
|
17728393 |
2007 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults.
|
18854428 |
2008 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
At the time of follow-up, AMS children exhibited 3-fold lower prevalence of severe obesity (11 vs. 35%, P = 0.004), greater insulin sensitivity (homeostasis model assessment of insulin resistance index 3.4 +/- 0.3 vs. 4.8 +/- 0.5, P = 0.02), improved lipid profile (cholesterol/high-density lipoprotein cholesterol 2.96 +/- 0.11 vs 3.40 +/- 0.18, P = 0.03; high-density lipoprotein cholesterol 1.50 +/- 0.05 vs. 1.35 +/- 0.05 mmol/liter, P = 0.04), lower C-reactive protein (0.88 +/- 0.17 vs. 2.00 +/- 0.34 microg/ml, P = 0.004), and leptin (11.5 +/- 1.5 vs.19.7 +/- 2.5 ng/ml, P = 0.005) and increased ghrelin (1.28 +/- 0.06 vs.1.03 +/- 0.06 ng/ml, P = 0.005) than BMS offspring (AMS vs. BMS, respectively, for all).
|
19820018 |
2009 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygous Leptin(145E/145E) mutant mice exhibited morbid obesity, accompanied by adipose hypertrophy, energy imbalance, and liver steatosis.
|
21151569 |
2010 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have assessed the incidence of LEP and MC4R mutations and associated hormonal profiles, in a cohort of randomly selected Pakistani children with early onset of severe obesity.
|
22463805 |
2012 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The discovery of the adipocyte hormone leptin and the demonstration that severe obesity in ob/ob and db/db mice results from mutation of genes encoding leptin and its receptor, respectively, ushered in a new era of obesity research.
|
23722910 |
2013 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Congenital leptin deficiency, caused by a very rare mutation in the gene encoding leptin, leads to severe obesity, hyperphagia and impaired satiety.
|
23799059 |
2013 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this issue, we have gathered together a group of essays by some of the world leaders in leptin research, including an overview by Dr Jeffrey Friedman who, in his seminal article in December 1994, described the adipocyte-derived hormone, the lack of which was responsible for the severe obesity in ob/ob mice and suggested that it should be named leptin.
|
25143632 |
2014 |