Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Previously, we demonstrated that Fsp27a is directly regulated by peroxisome proliferator-activated receptor γ (PPARγ) in fatty livers of genetically obese leptin deficient ob/ob mice and that Fsp27b may potentially be regulated by different factors transcriptionally as they both have a different promoter region.
|
31564684 |
2020 |
Fatty Liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Laboratory examinations and abdominal ultrasonography revealed diabetes mellitus, insulin-resistance, dyslipidemia, decreased serum leptin levels (2.2 ng/mL), elevated serum hepatobiliary enzyme levels and fatty liver.
|
31708526 |
2020 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
MF treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile and glucose sensitivity, and to a reduced fatty liver degeneration.
|
30870482 |
2019 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.
|
31167890 |
2019 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner.
|
31842467 |
2019 |
Fatty Liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement.
|
31071311 |
2019 |
Fatty Liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating WISP-1/CCN4 positively correlated with body mass index, body fat percentage, leptin and triglyceride levels, hip circumference and fatty liver index.
|
29129025 |
2018 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Aging is a significant risk factor for the development of obesity and hepatic steatosis associated with insulin and leptin resistance.
|
29575696 |
2018 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
High-fat diet (60% kcal) was used to induce fatty liver phenotype with parallel insulin and leptin resistance.
|
29660503 |
2018 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Alcohol exposure around conception increases obesity risk, alters plasma lipid and leptin profiles, and induces liver steatosis in a sex-specific manner.
|
29089335 |
2018 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver.
|
29507217 |
2018 |
Fatty Liver
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Melatonin reverses leptin methylation and expression and decreases inflammation and chronic liver steatosis not via apoptosis or histone deacetylation (HDAC).
|
30424542 |
2018 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the multiple regression analysis leptin, sObR, FLpI, waist-to-hip ratio, HbA1c, lipids, and HOMA-IR correlated independently with HS (P < 0.0001 for all).
|
30052309 |
2018 |
Fatty Liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that mSJH exerts an anti-hepatic steatosis effect via activation of leptin and associated signaling cascades related to lipid metabolism.
|
28358008 |
2017 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
CTD_human |
In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.
|
27712037 |
2017 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
MGD |
Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease.
|
25621497 |
2015 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
CTD_human |
Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study.
|
25554529 |
2015 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the liver effect of leptin independently of insulin sensitization and appetite suppression using hepatocyte-specific Pten-deficient (AlbCrePtenff) mouse, a model of severe fatty liver with insulin hypersensitivity.
|
25415231 |
2015 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
CTD_human |
Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.
|
24525044 |
2014 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21.
|
23839791 |
2014 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl.
|
23651953 |
2013 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin improved the fatty liver possibly by activating hepatic AMPK through the central and sympathetic nervous systems.
|
23024365 |
2012 |
Fatty Liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adoptive transfer of iNKT cells into obese mice or in vivo activation of iNKT cells via their lipid ligand, alpha-galactocylceramide, decreased body fat, triglyceride levels, leptin, and fatty liver and improved insulin sensitivity through anti-inflammatory cytokine production by adipose-derived iNKT cells.
|
22981538 |
2012 |
Fatty Liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In logistic regression analysis, only insulin resistance was associated with portal inflammation), lobular inflammation and steatosis; liver steatosis was related with leptin levels, too.
|
22530350 |
2012 |
Fatty Liver
|
0.600 |
Biomarker
|
disease |
MGD |
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet.
|
22118645 |
2011 |