|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This review focuses on the pathophysiology of insulin and adenosine receptors and l-arginine and adenosine membranes transporters giving an overview of the key adipokines leptin and adiponectin in the foetoplacental vasculature in GDM.
|
30660686 |
2020 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
This makes the Cartpt promoter more sensitive to leptin levels that predispose the GD offspring to fertility problems.
|
31150057 |
2019 |
|
Gestational Diabetes
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Increased first trimester leptin (OR = 1.166; CI = 1.104-1.233; p < 0.0001), resistin (p < 0.0001) and visfatin (p < 0.0001) were associated with GDM.
|
31836012 |
2019 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, 1,25(OH)<sub>2</sub>D<sub>3</sub> treatment in GDM placental explants blocked the aberrant, increased levels of leptin, TNF-α, and IL-6.
|
29575997 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM).
|
30303695 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Plasma leptin and adiponectin concentrations were measured in 160 women at approximately 12 weeks following pregnancy with GDM and compared with infant weight for length z-score at 1 year of age after adjustment for maternal and infant demographic variables.
|
29172804 |
2019 |
|
Gestational Diabetes
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Lower cord blood LEP methylation levels and certain maternal and fetal factors are associated with non-GDM macrosomia.
|
31117117 |
2019 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Leptin serum levels were significantly higher in women with early-onset GDM than in controls.
|
29696612 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Consequently, adipokines (adiponectin (APN), leptin (LPT), adipocyte fatty acid-binding protein, resistin, visfatin, omentin, vaspin, apelin, chemerin) secreted by adipose tissue, may contribute directly and/or indirectly, through the enhancement of chronic inflammation, aggravating insulin resistance and promoting GDM onset.
|
30990092 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
After adjustment for confounders including maternal pre-pregnancy BMI, GDM offspring had borderline higher leptin (p=0.06) and significantly lower FGF21 concentrations (p=0.006).
|
31639770 |
2019 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The umbilical cord serum FABP4 levels were higher in the GDM offspring and were directly associated with the maternal serum FABP4 and leptin levels, as well as the prepregnancy body mass index (BMI) and the BMI at and after delivery; however, they correlated negatively with birth weight and lipid parameters.
|
30818771 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Glucose, triglycerides, leptin, and lipocalin-2 were higher, while adiponectin was lower, in GDM (p < 0.05).
|
29898442 |
2019 |
|
Gestational Diabetes
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Secondly, maternal obesity (in the absence of gestational diabetes) was associated with (i) elevated DNA methylation of the leptin promoter on fetal side only, (ii) hypomethylation of the adiponectin promoter on the maternal side only, (iii) significantly low levels of leptin receptor protein (albeit in the absence of differences in mRNA levels and promoter DNA methylation), (iv) significantly low levels of adiponectin receptor 1 mRNA expression on the maternal side only, and (v) elevated DNA methylation of the adiponectin receptor 2 promoter on the maternal side only.
|
30732639 |
2019 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Serum FABP4 and leptin concentrations correlated positively in the GDM group.
|
30513800 |
2018 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of adipokines, leptin, and resistin were significantly increased, but adiponectin was decreased in OATs from patients with GDM compared with those without GDM.
|
30020508 |
2018 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Since leptin plasma levels and leptin expression are increased in placenta from gestational diabetes, we aimed to study the possible role of leptin on Aquaporin 9 expression in human placenta in vitro.
|
28942694 |
2018 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction.
|
29160594 |
2018 |
|
Gestational Diabetes
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Participants in the lowest tertile for leptin and SLeptinR had a 2.8-fold (95% CI 1.0-7.6) and a 5.7-fold (95% CI 1.9-17.3) higher risk of developing GDM compared with the highest tertile, respectively.
|
29270728 |
2018 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Leptin, resistin, malondialdehyde, xanthine oxidase and 8-isoprostane in maternal plasma, cord plasma and placenta were significantly higher while maternal adiponectin significantly lower in women with GDM (P < 0.05).
|
29399931 |
2018 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
This finding together with the positive association of chemerin and leptin with markers of insulin resistance, suggests that these adipokines and more especially chemerin and leptin accompanied by their adipose tissue expression could contribute to the increased insulin resistance and low grade inflammation that characterizes GDM-obese women.
|
29337272 |
2018 |
|
Gestational Diabetes
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The increased messenger RNA expression of leptin and resistin in adipose tissue from GDM was reduced by AM22-52 treatment.
|
28666334 |
2017 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Cross-sectional analysis of 236 participants in the PPSDiab Study (cohort study of women 3-16 months after delivery, 152 after gestational diabetes (pGDM), 84 after normoglycemic pregnancy (control subjects); consecutively recruited 2011-16); medical history, physical examination with bioelectrical impedance analysis (BIA), whole body magnetic resonance imaging (MRI) (n = 154), 5-point oral glucose tolerance test, cardiopulmonary exercise testing, clinical chemistry including fasting plasma leptin; statistical analysis with Mann-Whitney U and t -test, Spearman correlation coefficient, multiple linear regression.
|
28609470 |
2017 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy.
|
28068986 |
2017 |
|
Gestational Diabetes
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Preadipocytes isolated from male O-GDM and O-T1DM and cultured in vitro displayed decreased LEP promoter methylation, increased leptin gene expression, and elevated leptin secretion throughout differentiation, compared with adipocytes established from male O-BP.
|
28204515 |
2017 |
|
Gestational Diabetes
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Leptin, progesterone, estradiol estimated in this study were increased in the gestational diabetes mellitus women and fairly predicted gestational diabetes in the non-diabetics pregnant women.
|
28732072 |
2017 |