|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F<sub>2t</sub> isoprostanes (F<sub>2</sub> -IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F<sub>2</sub> -IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance.
|
31657510 |
2020 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In the nonpregnant state, female Sprague-Dawley rats offered a 3-wk free-choice high-fat, high-sucrose diet had greater energy intake, adiposity, serum leptin, and triglyceride concentrations compared with rats fed with standard chow and developed glucose intolerance.
|
30758976 |
2019 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In Chinese individuals without diabetes, no significant evidence for the potential discriminatory value of adiponectin, leptin or their ratio in the identification of IGT on top of conventional risk factors was observed.
|
30399195 |
2018 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Type 2 diabetes risk, early impaired glucose tolerance and insulin resistance were predicted with >98% specificity and sensitivity by comparing fasting glucose levels to the estimated Matsuda Index based on fasting levels of insulin, adiponectin and leptin with or without oxidative lineolate metabolites.
|
29610560 |
2018 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
<i>In vivo</i> exposure to biologically relevant doses of DBT during perinatal development led to increased fat storage, elevated leptin levels in plasma, and glucose intolerance in mice.
|
29787037 |
2018 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
HF dams had greater fat mass, higher plasma leptin, lower plasma adiponectin, and impaired glucose tolerance during pregnancy.
|
28332771 |
2017 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Overall, HFD resulted in increased caloric intake, insulin resistance, impaired glucose tolerance and higher circulating levels of leptin, while PNS increased the leptin/adiponectin ratio, an index of metabolic risk in adult male subjects.
|
28706476 |
2017 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
SD rats administered leptin immunogen also showed glucose intolerance, β- cell reduction in the pancreas, and deregulation of JAK2-STAT3/PI3K signaling, indicating that Lep rats were at risk of diabetes.
|
28242305 |
2017 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.
|
27841948 |
2017 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with WT littermates, adult Kiss1r KO females displayed dramatically higher BW, leptin levels, and adiposity, along with strikingly impaired glucose tolerance.
|
24937427 |
2014 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.
|
24150608 |
2014 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
RGD |
Creation and preliminary characterization of a leptin knockout rat.
|
22948215 |
2012 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).
|
21315688 |
2011 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that placental leptin gene DNA methylation levels were correlated with glucose levels (2-h post-OGTT) in women with IGT (fetal side: ρ=-0.44, P≤0.05; maternal side: ρ=0.53, P≤0.01) and with decreased leptin gene expression (n=48; ρ≥-0.30, P≤0.05) in the whole cohort.
|
20724651 |
2010 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Other adipokines were examined, and both pioglitazone and metformin decreased plasma levels of resistin in IGT subjects, and pioglitazone (but not metformin) decreased plasma levels of leptin.
|
16118250 |
2006 |
|
Impaired glucose tolerance
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Abnormalities of sympathetic effects, including disturbances of leptin and beta3-adrenergic receptor signalling, are likely to cause obesity and impaired glucose tolerance in rodents and humans.
|
10855527 |
2000 |
|
Impaired glucose tolerance
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Subjects with normoglycaemia (n = 117) and impaired glucose tolerance (n = 27, WHO criteria) were included in the analysis.Leptin values were higher in women.
|
9632122 |
1998 |
|
Impaired glucose tolerance
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
The regional difference in leptin expression was similar in the patients with impaired glucose tolerance/type-2 diabetes and those with normal glucose tolerance.
|
9013743 |
1996 |