LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE In genetically obese mice with otherwise wild-type islets, disulfide-linked complexes of proinsulin are more abundant, and leptin receptor-deficient mice, the further increase of such complexes tracks with the onset of islet insulin deficiency and diabetes. 31184302 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 GeneticVariation group BEFREE Mice were subjected to diabetes mellitus either by streptozotocin injections (type 1 diabetes mellitus model) or by crossing into mice carrying a leptin receptor mutation (db/db; type 2 diabetes mellitus model) and monitored for remodeling and cardiac function. 31195810 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Thus, Cas9-generated Lep and Lepr KO mouse lines will be easier for genotyping, to maintain the lines, and to use for future obesity and diabetes research. 29343656 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 AlteredExpression group BEFREE The db/db mouse is an animal model of diabetes in which leptin receptor activity is deficient resulting accelerated cardiomyopathy when exposed to angiotensin (AT). 27884680 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity. 27623943 2016
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE Furthermore, lepr (leptin receptor) gene was downregulated by maternal FR, indicating its potential role in induction of obesity and diabetes. 24754856 2014
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE The leptin receptor (LEPR) has been implicated in obesity and diabetes. 20624279 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group BEFREE These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits. 20167575 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 GeneticVariation group LHGDN Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2. 18632178 2008
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 GeneticVariation group LHGDN [Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy]. 18050615 2007
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 Biomarker group CTD_human Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice. 15028607 2003
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 GeneticVariation group BEFREE As part of an effort to identify informative molecular markers for genetic analysis of human pedigrees segregating for obesity, we have developed a genetic map of human 1p in the region of the OB receptor (OBR), the gene that is defective in murine diabetes (Obrdb) and rat Zucker fatty (Obrfa) mutations located on mid-chromosome 4 and chromosome 5, respectively. 8743992 1996