Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In genetically obese mice with otherwise wild-type islets, disulfide-linked complexes of proinsulin are more abundant, and leptin receptor-deficient mice, the further increase of such complexes tracks with the onset of islet insulin deficiency and diabetes.
|
31184302 |
2019 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mice were subjected to diabetes mellitus either by streptozotocin injections (type 1 diabetes mellitus model) or by crossing into mice carrying a leptin receptor mutation (db/db; type 2 diabetes mellitus model) and monitored for remodeling and cardiac function.
|
31195810 |
2019 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, Cas9-generated Lep and Lepr KO mouse lines will be easier for genotyping, to maintain the lines, and to use for future obesity and diabetes research.
|
29343656 |
2018 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The db/db mouse is an animal model of diabetes in which leptin receptor activity is deficient resulting accelerated cardiomyopathy when exposed to angiotensin (AT).
|
27884680 |
2017 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity.
|
27623943 |
2016 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, lepr (leptin receptor) gene was downregulated by maternal FR, indicating its potential role in induction of obesity and diabetes.
|
24754856 |
2014 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The leptin receptor (LEPR) has been implicated in obesity and diabetes.
|
20624279 |
2010 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits.
|
20167575 |
2010 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.
|
18632178 |
2008 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
[Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy].
|
18050615 |
2007 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.
|
15028607 |
2003 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As part of an effort to identify informative molecular markers for genetic analysis of human pedigrees segregating for obesity, we have developed a genetic map of human 1p in the region of the OB receptor (OBR), the gene that is defective in murine diabetes (Obrdb) and rat Zucker fatty (Obrfa) mutations located on mid-chromosome 4 and chromosome 5, respectively.
|
8743992 |
1996 |