LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Disease: Hyperinsulinism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673 2019
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. 29988851 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models. 24384915 2014
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487 2014
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. 22949526 2012
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 AlteredExpression disease BEFREE Disruption of the signal transducer and activator of transcription 3 (STAT3) in the hypothalamic neurons expressing leptin receptor, results in severe obesity, hyperglycaemia, and hyperinsulinemia. 19390493 2009
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat. 15093691 2004
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 AlteredExpression disease BEFREE Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance. 11596667 2001
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease CTD_human "Estrone treatment dissociates primary versus secondary consequences of ""diabetes"" (db) gene expression in mice." 3519326 1986
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 Biomarker disease HPO