|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
With the example of gal-4 which functions as a tumor suppressor in CRC cells, we were able to prove that cell surface binding of the lectin not only markedly influences the cell proteome, but also has a bearing on malignancy-associated intracellular protein phosphorylation.
|
30550624 |
2019 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
The promoter hypermethylation of LGALS4 (>2.51, log10 scale) revealed a positive correlation with high levels of both histological grade and tumor T category and with lymph node metastasis (all P≤0.001).
|
28423602 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
By comparing the number of RBCs attaching to each tumor cell, we found that cells with high pre-incubation expression levels of galectin-4 attached significantly more RBCs than those with low expression levels (p < 1 × 10<sup>-7</sup>).
|
28293788 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To facilitate phenotypic analysis of tumor progression in imaginal discs, here we describe a protocol for genetic experiments using the GAL4-UAS system to induce neoplastic tumors in wing imaginal discs.
|
28784954 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Intravenous injection of a GAL4 regulated bicistronic adenovirus vector constructed to express βG under the control of the PSA promoter (Ad/PSAP‑GV16‑βG) and the application of DOX‑GA3 strongly inhibited tumor growth and prolonged the survival time of tumor‑bearing nude mice.
|
26648021 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LGALS4, encoding a galactoside-binding protein involved in cell-cell and cell-matrix interactions, was recently shown to be a tumor suppressor in colorectal cancer.
|
22613842 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study also shows that gal-4 exhibits tumor suppressive effects in CRC cells in vitro.
|
21064109 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry was performed for LGALS4 (Galectin 4), ACS5 (Acyl-CoA synthetase) and CLU (Clusterin) proteins: LGALS4 was highly up-regulated, particularly in the most differentiated tumors, while CLU was lost in all tumors.
|
19903339 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In particular, galectin 4 (LGALS4) was highly and specifically expressed in MOC, but expressed at lower levels in benign mucinous cysts and borderline (atypical proliferative) tumours, supporting a malignant progression model of MOC.
|
16508639 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EYA2 was found to function as transcriptional activator in ovarian cancer cells by Gal4 assay and to promote tumor growth in vivo in xenograft models.
|
15705892 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No significant correlation was observed between decreased expression of galectin-4 and the degree of differentiation of the tumor or Duke's state.
|
9310382 |
1997 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines.
|
28345468 |
2017 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Galectine-4 (gal-4), encoded by the LGALS4 gene, was recently shown to exhibit a tumor suppressive effect in colorectal carcinoma and pancreatic adenocarcinoma, although how the expression of this gene is regulated remains unknown.
|
28423602 |
2017 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Previously, galectin-4 has been shown to have a role in cancer progression and metastasis and it is found upregulated in many solid tumours, including colorectal cancer (CRC).
|
26681582 |
2016 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Conversely, the expression levels of galectin-4 were significantly lower in CRC samples and its precursor lesions with dysplasia or inflammation.
|
23378274 |
2013 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
LGALS4, encoding a galactoside-binding protein involved in cell-cell and cell-matrix interactions, was recently shown to be a tumor suppressor in colorectal cancer.
|
22613842 |
2012 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The goal of this work was to determine the function of gal-4 in CRC.
|
21064109 |
2011 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.
|
9310382 |
1997 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Detection of malignancy-associated phosphoproteome changes in human colorectal cancer induced by cell surface binding of growth-inhibitory galectin-4.
|
30550624 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Detection of malignancy-associated phosphoproteome changes in human colorectal cancer induced by cell surface binding of growth-inhibitory galectin-4.
|
30550624 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, galectin-4 engaged with C1GALT1-dependent O-glycans to promote castration resistance and metastasis by activating receptor tyrosine kinase signaling and cancer cell stemness properties mediated by SRY-box 9 (SOX9).
|
29906246 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, galectin-4 engaged with C1GALT1-dependent O-glycans to promote castration resistance and metastasis by activating receptor tyrosine kinase signaling and cancer cell stemness properties mediated by SRY-box 9 (SOX9).
|
29906246 |
2018 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The ectopic expression of gal-4 in cancer cell lines was used to address its biological function in UC in vitro.
|
28423602 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The ectopic expression of gal-4 in cancer cell lines was used to address its biological function in UC in vitro.
|
28423602 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines.
|
28345468 |
2017 |