LGALS4, galectin 4, 3960

N. diseases: 73; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression disease BEFREE Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines. 28345468 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Galectine-4 (gal-4), encoded by the LGALS4 gene, was recently shown to exhibit a tumor suppressive effect in colorectal carcinoma and pancreatic adenocarcinoma, although how the expression of this gene is regulated remains unknown. 28423602 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression disease BEFREE Previously, galectin-4 has been shown to have a role in cancer progression and metastasis and it is found upregulated in many solid tumours, including colorectal cancer (CRC). 26681582 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression disease BEFREE Conversely, the expression levels of galectin-4 were significantly lower in CRC samples and its precursor lesions with dysplasia or inflammation. 23378274 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE LGALS4, encoding a galactoside-binding protein involved in cell-cell and cell-matrix interactions, was recently shown to be a tumor suppressor in colorectal cancer. 22613842 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE The goal of this work was to determine the function of gal-4 in CRC. 21064109 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression disease BEFREE Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer. 9310382 1997