LGALS4, galectin 4, 3960

N. diseases: 73; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.040 Biomarker disease BEFREE This study was performed to validate the prognostic value of galectin 4 in a larger cohort of pancreatic cancer patients undergoing surgical resection. 30663442 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.040 AlteredExpression disease BEFREE According to subgroup analysis, high levels of galectin-1 were significantly correlated with worse OS in pancreatic cancer (HR, 4.77; 95% CI 2.47-9.21), while high levels of tandem-repeat galectins (galectin-4 or galectin-9) predicted both better OS (HR, 0.63; 95% CI 0.46-0.86) and disease-free survival (DFS) (HR, 0.63; 95% CI 0.48-0.83). 31832021 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.040 Biomarker disease BEFREE However, the putative function of Gal-4 in tumor progression of pancreatic cancer is still incompletely understood. 23824659 2013
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.040 Biomarker disease BEFREE In this chapter, we review our experience using the Gal4/UAS system to model KRAS-initiated pancreatic cancer in zebrafish, as well as our early efforts using this system to study the influence of other cooperating oncogenes. 21951538 2011