Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Diabetic Nephropathy
|
0.110 |
Biomarker
|
disease |
BEFREE |
Although genome-wide significance with type 2 diabetes was not found for any of these 25 SNPs, several genes, including RPS12, LIMK2, and SFI1 are strong candidates for diabetic nephropathy.
|
21150874 |
2011 |
Diabetic Nephropathy
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study for diabetic nephropathy genes in African Americans.
|
21150874 |
2011 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
While knockdown of either LIMK1 or LIMK2 only minimally influenced invasion in culture, simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells (TIC) in both Boyden chamber and 3D hyaluronic acid spheroid invasion assays.
|
31641031 |
2020 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Further, we showed that LIMK2 was a downstream effector in the LINC00460-induced promotion of metastasis in CRC cells HT29 and LOVO.
|
30863183 |
2019 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways.
|
30886151 |
2019 |
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Based on our findings, we suggest that cofilin-1 is crucial to switching from epithelial to mesenchymal-like morphology and cell migration and invasion by regulating actin cytoskeleton organization through activation of RhoA-LIMK2-cofilin-1 signaling, impacting the cell-cell adhesion organization of colon cancer cells in EMT.
|
30296500 |
2019 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
LIMK2 overexpression promoted proliferation, migration and invasion of BC cells, while LIMK2 depletion inhibited cell invasion and viability and induced growth arrest in vitro and in vivo.
|
30006972 |
2019 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways.
|
30886151 |
2019 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
LIMK1 and, more recently, LIMK2 have been shown to be involved in cancer development and metastasis, resistance of cancer cells to microtubule-targeted treatments, neurological diseases, and viral infection.
|
30373762 |
2018 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Gain- and loss-of-function assays revealed that LIMK2 inhibits cell proliferation via cell cycle arrest at the G1-S transition and suppresses the ability of cell metastasis by restricting the EMT process.
|
29970879 |
2018 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells.
|
28938584 |
2017 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells.
|
28938584 |
2017 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis.
|
23585469 |
2014 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis.
|
23585469 |
2014 |
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay.
|
20047470 |
2009 |
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay.
|
20047470 |
2009 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Phosphorylation-dead TWIST1 acts as dominant negative and fully prevents EMT and tumor formation in vivo, thereby highlighting the significance of LIMK2-TWIST1 signaling axis in CRPC.
|
30716360 |
2019 |
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Limk2 deletion increased colon tumour size in a colitis-associated colorectal mouse cancer model.
|
23585469 |
2014 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that inhibition of LIMK2 activity may be used for the treatment of tumors resistant to microtubule-destabilizing drugs.
|
19881550 |
2010 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells.
|
20047470 |
2009 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Specific targeting of metastatic and malignant properties of tumor cells by LIMK-2 ribozyme may serve as an effective therapy for invasive tumors with minimum effect on the surrounding normal cells.
|
15026997 |
2004 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We also identified TWIST1 as a direct substrate of LIMK2, which uncovered the molecular mechanism of LIMK2-induced malignancy.
|
30716360 |
2019 |