LIMK2, LIM domain kinase 2, 3985

N. diseases: 44; N. variants: 6
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Further, we showed that LIMK2 was a downstream effector in the LINC00460-induced promotion of metastasis in CRC cells HT29 and LOVO. 30863183 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. 30886151 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE LIMK1 and, more recently, LIMK2 have been shown to be involved in cancer development and metastasis, resistance of cancer cells to microtubule-targeted treatments, neurological diseases, and viral infection. 30373762 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Gain- and loss-of-function assays revealed that LIMK2 inhibits cell proliferation via cell cycle arrest at the G1-S transition and suppresses the ability of cell metastasis by restricting the EMT process. 29970879 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells. 28938584 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. 23585469 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay. 20047470 2009