LIMK2, LIM domain kinase 2, 3985

N. diseases: 44; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker disease BEFREE Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. 30886151 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker disease BEFREE Taken together, our study revealed that BMPR2 functions as a prometastatic oncogene <i>in vitro</i> and <i>in vivo</i> with the activation of the RhoA-ROCK-LIMK2 pathway and may represent a potential therapeutic target for osteosarcoma. 28938584 2017