LIMK2, LIM domain kinase 2, 3985

N. diseases: 44; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE While knockdown of either LIMK1 or LIMK2 only minimally influenced invasion in culture, simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells (TIC) in both Boyden chamber and 3D hyaluronic acid spheroid invasion assays. 31641031 2020
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 AlteredExpression phenotype BEFREE Based on our findings, we suggest that cofilin-1 is crucial to switching from epithelial to mesenchymal-like morphology and cell migration and invasion by regulating actin cytoskeleton organization through activation of RhoA-LIMK2-cofilin-1 signaling, impacting the cell-cell adhesion organization of colon cancer cells in EMT. 30296500 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE LIMK2 overexpression promoted proliferation, migration and invasion of BC cells, while LIMK2 depletion inhibited cell invasion and viability and induced growth arrest in vitro and in vivo. 30006972 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. 30886151 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells. 28938584 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. 23585469 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay. 20047470 2009